F
Francesca Pischiutta
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 27
Citations - 1218
Francesca Pischiutta is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Traumatic brain injury & Mesenchymal stem cell. The author has an hindex of 15, co-authored 20 publications receiving 915 citations.
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Journal ArticleDOI
The ischemic environment drives microglia and macrophage function.
Stefano Fumagalli,Stefano Fumagalli,Carlo Perego,Francesca Pischiutta,Elisa R. Zanier,Maria Grazia De Simoni +5 more
TL;DR: The selective responses of microglia and macrophages to hypoxia after stroke are discussed and relevant markers are reviewed with the aim of defining the different subpopulations of myeloid cells that are recruited to the injured site.
Journal ArticleDOI
Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma
Elisa R. Zanier,Francesca Pischiutta,Loredana Riganti,Federica Marchesi,Elena Turola,Stefano Fumagalli,Carlo Perego,E Parotto,E Parotto,Paola Vinci,Pietro Veglianese,Giovanna D'Amico,Claudia Verderio,Maria Grazia De Simoni +13 more
TL;DR: Evidence is found that MSCs can drive the M transcriptional environment and induce the acquisition of an early, persistent M2-beneficial phenotype both in vivo and in vitro.
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Human umbilical cord blood mesenchymal stem cells protect mice brain after trauma.
Elisa R. Zanier,Mery Montinaro,Mariele Viganò,Pia Villa,Stefano Fumagalli,Francesca Pischiutta,Luca Longhi,Matteo Luigi Giuseppe Leoni,Paolo Rebulla,Nino Stocchetti,Lorenza Lazzari,Maria Grazia De Simoni +11 more
TL;DR: These findings indicate that human umbilical cord blood mesenchymal stem cells stimulate the injured brain and evoke trophic events, microglia/macrophage phenotypical switch, and glial scar inhibitory effects that remodel the brain and lead to significant improvement of neurologic outcome.
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Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury
Simonetta Papa,Ilaria Caron,Eugenio Erba,Nicolò Panini,Massimiliano De Paola,Alessandro Mariani,Claudio Colombo,Raffaele Ferrari,Diego Pozzer,Elisa R. Zanier,Francesca Pischiutta,Jacopo Lucchetti,Andrea Bassi,Gianluca Valentini,Giulio Alfredo Simonutti,Filippo Rossi,Davide Moscatelli,Gianluigi Forloni,Pietro Veglianese +18 more
TL;DR: It is shown that a treatment with nanoparticles loaded with minocycline when administered acutely in a SCI mouse model is able to efficiently modulate the resident microglial cells reducing the pro-inflammatory response, maintaining a pro-regenerative milieu and ameliorating the behavioral outcome up to 63 days post injury.
Journal ArticleDOI
Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice
Elisa R. Zanier,Stefano Fumagalli,Stefano Fumagalli,Carlo Perego,Francesca Pischiutta,Maria Grazia De Simoni +5 more
TL;DR: Specific morphological features that M/M acquire in response to different acute insults are defined by applying a sensitive and readily applicable approach to cell morphological analysis in the brain tissue.