Francesca Pischiutta

TL;DR: The selective responses of microglia and macrophages to hypoxia after stroke are discussed and relevant markers are reviewed with the aim of defining the different subpopulations of myeloid cells that are recruited to the injured site.

TL;DR: Evidence is found that MSCs can drive the M transcriptional environment and induce the acquisition of an early, persistent M2-beneficial phenotype both in vivo and in vitro.

TL;DR: These findings indicate that human umbilical cord blood mesenchymal stem cells stimulate the injured brain and evoke trophic events, microglia/macrophage phenotypical switch, and glial scar inhibitory effects that remodel the brain and lead to significant improvement of neurologic outcome.

TL;DR: It is shown that a treatment with nanoparticles loaded with minocycline when administered acutely in a SCI mouse model is able to efficiently modulate the resident microglial cells reducing the pro-inflammatory response, maintaining a pro-regenerative milieu and ameliorating the behavioral outcome up to 63 days post injury.

TL;DR: Specific morphological features that M/M acquire in response to different acute insults are defined by applying a sensitive and readily applicable approach to cell morphological analysis in the brain tissue.