F
Francesca Sanvito
Researcher at Vita-Salute San Raffaele University
Publications - 99
Citations - 7192
Francesca Sanvito is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Genetic enhancement & Transplantation. The author has an hindex of 37, co-authored 81 publications receiving 6174 citations. Previous affiliations of Francesca Sanvito include University of Geneva & MolMed.
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Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Margherita Norelli,Barbara Camisa,Giulia Barbiera,Laura Falcone,Ayurzana Purevdorj,Marco Genua,Francesca Sanvito,Maurilio Ponzoni,Claudio Doglioni,Patrizia Cristofori,Catia Traversari,Claudio Bordignon,Claudio Bordignon,Fabio Ciceri,Renato Ostuni,Chiara Bonini,Monica Casucci,Attilio Bondanza +17 more
TL;DR: A mouse model recapitulating key features of CRS and neurotoxicity is described, offering a therapeutic strategy to tackle neurotoxicity and open new avenues to safer CAR T cell therapies.
Journal ArticleDOI
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration
Eugenio Montini,Daniela Cesana,Manfred G. Schmidt,Francesca Sanvito,Maurilio Ponzoni,Cynthia C. Bartholomae,Lucia Sergi Sergi,Fabrizio Benedicenti,Alessandro Ambrosi,Clelia Di Serio,Claudio Doglioni,Christof von Kalle,Luigi Naldini +12 more
TL;DR: The results validate a much-needed platform to assess vector safety and provide direct evidence that prototypical lentiviral vectors have low oncogenic potential, highlighting a major rationale for application to gene therapy.
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The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
Eugenio Montini,Daniela Cesana,Manfred Schmidt,Francesca Sanvito,Cynthia C. Bartholomae,Marco Ranzani,Fabrizio Benedicenti,Lucia Sergi Sergi,Alessandro Ambrosi,Maurilio Ponzoni,Claudio Doglioni,Clelia Di Serio,Christof von Kalle,Luigi Naldini +13 more
TL;DR: It is determined that substantially greater LV integration loads are required to approach the same oncogenic risk as gammaRVs, which strongly support the use of SIN viral vector platforms and show that ISS can substantially modulate genotoxicity.
Journal ArticleDOI
The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells
Bernard Degryse,Tiziana Bonaldi,Paola Scaffidi,Susanne Müller,Massimo Resnati,Francesca Sanvito,Gianluigi Arrigoni,Marco Bianchi +7 more
TL;DR: HMG1 has all the hallmarks of a molecule that can promote atherosclerosis and restenosis after vascular damage, and it is shown that HMG1 can be released by damage or necrosis of a variety of cell types, including endothelial cells.
Journal ArticleDOI
Tumor-mediated liver X receptor-[alpha] activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
Eduardo J. Villablanca,Laura Raccosta,Dan Zhou,Raffaella Fontana,Daniela Maggioni,Aurora Negro,Francesca Sanvito,Maurilio Ponzoni,Barbara Valentinis,Marco Bregni,Alessandro Prinetti,Knut R. Steffensen,Sandro Sonnino,Jan-Åke Gustafsson,Jan-Åke Gustafsson,Claudio Doglioni,Claudio Bordignon,Catia Traversari,Vincenzo Russo +18 more
TL;DR: It is reported that human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing DCs and, therefore, their migration to lymphoid organs and the manipulation of this pathway could restore antitumor immunity in individuals with cancer.