K
Knut R. Steffensen
Researcher at Karolinska Institutet
Publications - 99
Citations - 6046
Knut R. Steffensen is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Liver X receptor & Nuclear receptor. The author has an hindex of 43, co-authored 97 publications receiving 5540 citations. Previous affiliations of Knut R. Steffensen include University of Houston & Karolinska University Hospital.
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Journal ArticleDOI
Tumor-mediated liver X receptor-[alpha] activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
Eduardo J. Villablanca,Laura Raccosta,Dan Zhou,Raffaella Fontana,Daniela Maggioni,Aurora Negro,Francesca Sanvito,Maurilio Ponzoni,Barbara Valentinis,Marco Bregni,Alessandro Prinetti,Knut R. Steffensen,Sandro Sonnino,Jan-Åke Gustafsson,Jan-Åke Gustafsson,Claudio Doglioni,Claudio Bordignon,Catia Traversari,Vincenzo Russo +18 more
TL;DR: It is reported that human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing DCs and, therefore, their migration to lymphoid organs and the manipulation of this pathway could restore antitumor immunity in individuals with cancer.
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Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
TL;DR: The current status of the understanding of the LXR biology and pharmacology is discussed, with an emphasis on the molecular aspects of LXR signaling that constitute the potential of LXRs as drug targets.
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Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression
Jong Bae Seo,Hyang Mi Moon,W. S. Kim,Yun Sok Lee,Hyun Woo Jeong,Eung Jae Yoo,Jungyeob Ham,Heonjoong Kang,Myoung Gyu Park,Knut R. Steffensen,Thomas M. Stulnig,Jan-Åke Gustafsson,Sang Dai Park,Jae Bum Kim +13 more
TL;DR: It is shown that LXR activation stimulated the execution of adipogenesis, as determined by lipid droplet accumulation and adipocyte-specific gene expression in vivo and in vitro.
Journal ArticleDOI
Putative Metabolic Effects of the Liver X Receptor (LXR)
TL;DR: The physiological roles of LXR indicate that it is an interesting potential target for drug treatment of diabetes and seems to have an important role in the regulation of glucocorticoid action and in the overall energy homeostasis suggested by its putative regulatory effect on leptin and uncoupling protein 1.
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Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites.
Michael Boergesen,Thomas Åskov Pedersen,Barbara Gross,Simon J. van Heeringen,Dik Hagenbeek,Christian Bindesbøll,Christian Bindesbøll,Sandrine Caron,Fanny Lalloyer,Knut R. Steffensen,Hilde I. Nebb,Jan-Åke Gustafsson,Jan-Åke Gustafsson,Hendrik G. Stunnenberg,Bart Staels,Susanne Mandrup +15 more
TL;DR: The combination of sequence analysis of shared binding regions and sequential ChIP on selected sites indicate that LXR-RXR and PPARα-RxR bind to degenerate response elements in a mutually exclusive manner.