S
Sandro Sonnino
Researcher at University of Milan
Publications - 330
Citations - 13694
Sandro Sonnino is an academic researcher from University of Milan. The author has contributed to research in topics: Ganglioside & Ceramide. The author has an hindex of 62, co-authored 319 publications receiving 12567 citations. Previous affiliations of Sandro Sonnino include University of Siena & University of Washington.
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Journal ArticleDOI
iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
David C. Schöndorf,Massimo Aureli,Fiona E. McAllister,Christopher J. Hindley,Florian Mayer,Benjamin Schmid,S. Pablo Sardi,Manuela Valsecchi,Susanna A. Hoffmann,Lukas Kristoffer Schwarz,Ulrike Hedrich,Daniela Berg,Lamya S. Shihabuddin,Jing Hu,Jan Pruszak,Steven P. Gygi,Sandro Sonnino,Thomas Gasser,Michela Deleidi +18 more
TL;DR: Induced pluripotent stem cells are generated from subjects with GD and PD harbouring GBA1 mutations and complex changes in the autophagic/lysosomal system and intracellular calcium homeostasis, which underlie vulnerability to neurodegeneration are provided.
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Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.
Kazuya Kabayama,Takashige Sato,Kumiko Saito,Nicoletta Loberto,Alessandro Prinetti,Sandro Sonnino,Masataka Kinjo,Yasuyuki Igarashi,Jin-ichi Inokuchi +8 more
TL;DR: A pathological feature of insulin resistance in adipocytes is proposed by dissociation of the IR–Cav1 complex by the interactions of IR with GM3 in microdomains.
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Gangliosides as components of lipid membrane domains
TL;DR: Ganglioside features are discussed in this review to show how gangliosides are responsible for the formation of cell lipid membrane domains characterized by a strong positive curvature.
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Tumor-mediated liver X receptor-[alpha] activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
Eduardo J. Villablanca,Laura Raccosta,Dan Zhou,Raffaella Fontana,Daniela Maggioni,Aurora Negro,Francesca Sanvito,Maurilio Ponzoni,Barbara Valentinis,Marco Bregni,Alessandro Prinetti,Knut R. Steffensen,Sandro Sonnino,Jan-Åke Gustafsson,Jan-Åke Gustafsson,Claudio Doglioni,Claudio Bordignon,Catia Traversari,Vincenzo Russo +18 more
TL;DR: It is reported that human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing DCs and, therefore, their migration to lymphoid organs and the manipulation of this pathway could restore antitumor immunity in individuals with cancer.
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Promotion of neuritogenesis in mouse neuroblastoma cells by exogenous gangliosides. Relationship between the effect and the cell association of ganglioside GM1.
TL;DR: Under the experimental conditions used, the stimulation of neuro‐2a cell differentiation by GM1 is related to changes of the plasma membrane properties following association of exogenous GM1 molecules, which would facilitate the spontaneous process of differentiation, or enhance cell responsiveness to differentiating factors present in the serum.