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Francesca Stillitano
Researcher at University of Florence
Publications - 26
Citations - 1354
Francesca Stillitano is an academic researcher from University of Florence. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 21 publications receiving 1218 citations.
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Journal ArticleDOI
Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach.
Laura Sartiani,Esther Bettiol,Francesca Stillitano,Alessandro Mugelli,Elisabetta Cerbai,Marisa Jaconi +5 more
TL;DR: It is shown that human embryonic stem cell‐derived cardiomyocytes mature over time during in vitro differentiation, approaching an adult phenotype.
Journal ArticleDOI
Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy
Raffaele Coppini,Cecilia Ferrantini,Lina Yao,Peidong Fan,Martina Del Lungo,Francesca Stillitano,Laura Sartiani,Benedetta Tosi,Silvia Suffredini,Chiara Tesi,Magdi H. Yacoub,Iacopo Olivotto,Luiz Belardinelli,Corrado Poggesi,Elisabetta Cerbai,Alessandro Mugelli +15 more
TL;DR: A specific set of functional changes in human HCM myocardium are highlighted that stem from a complex remodeling process involving alterations of CaMKII-dependent signaling, rather than being a direct consequence of the causal sarcomeric mutations.
Journal ArticleDOI
Molecular basis of funny current (If) in normal and failing human heart.
Francesca Stillitano,Giuseppe Lonardo,Giuseppe Lonardo,Stephen Zicha,András Varró,András Varró,Elisabetta Cerbai,Alessandro Mugelli,Stanley Nattel +8 more
TL;DR: HCN4 is the predominant channel subtype in normal human heart, and its expression is further amplified by disease, and may play a role in ventricular and atrial arrhythmogenesis in heart failure.
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Enhanced ROS production by NADPH-oxidase is correlated to changes in antioxidant enzyme activity in human heart failure
Elisabetta Borchi,V. Bargelli,Francesca Stillitano,Carla Giordano,Mariangela Sebastiani,Paolo Nassi,Giulia d'Amati,Elisabetta Cerbai,Chiara Nediani +8 more
TL;DR: It is concluded that in human failing RV and LV, oxidative stress is associated with activation of antioxidant enzyme activity, likely due to post-translational modifications and more evident in LV.
Journal ArticleDOI
Long‐term treatment with ivabradine in post‐myocardial infarcted rats counteracts f‐channel overexpression
Silvia Suffredini,Francesca Stillitano,Laura Comini,M. Bouly,Simona Brogioni,Claudio Ceconi,Roberto Ferrari,Alessandro Mugelli,Elisabetta Cerbai +8 more
TL;DR: Functional/molecular changes in If, the specific target of ivabradine, in the failing atrial and ventricular myocytes where this current is up‐regulated as a consequence of maladaptive remodelling are investigated.