Giulia d'Amati

TL;DR: Determining appropriate EMB use in the context of current diagnostic strategies for cardiac diseases and providing recommendations for its rational utilization and providing standard criteria and guidance for appropriate tissue triage and pathological analysis is suggested.

TL;DR: The coronary microvasculature (vessels <300 μm in diameter) cannot be directly imaged in vivo, but a number of invasive and non-invasive techniques, each with relative advantages and pitfalls, can be used to assess parameters that depend directly on coronary microvascular function as discussed by the authors.

TL;DR: Leptin-evoked vasorelaxation evoked by leptin is heterogeneous and related to the vascular bed, and the inhibition of nitric oxide synthase by NG-nitro-L-arginine-methyl ester does not modify blood pressure response to leptin, suggesting a predominant role of the EDHF mechanism in the hypotensive effect of leptin.

TL;DR: These guidelines represent the minimum standard that is required in the routine autopsy practice for the adequate investigation of SCD and are believed to improve the standards of autopsy practice, allow meaningful comparisons between different communities and regions, and permit the identification of emerging patterns of diseases causing SCD.

TL;DR: Giordano et al. show that mitochondrial DNA content and mitochondrial mass are both increased in tissues and cells from unaffected mutation carriers relative to affected relatives and control individuals, suggesting upregulation of mitochondrial biogenesis may represent a therapeutic target.