Showing papers by "Francesco E. Pontieri published in 2001"
TL;DR: Findings indicate that pretreatment with WIN55212.2 produces cross-sensitization to heroin in the rat, which might reflect long-lasting changes of receptor population or transcriptional mechanisms in the mesolimbic system.
78 citations
TL;DR: A reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of Parkinson's disease is demonstrated, contributing to the understanding of the peripheral dopamine system in PD.
Abstract: There is increasing interest in the identification of biological markers for the early diagnosis of Parkinson's disease (PD). Previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (PBL) in PD. Here we demonstrate a reduction of dopamine transporter immunoreactivity in PBL in the early clinical stages of the disease. These findings contribute to our understanding of the peripheral dopamine system in PD.
72 citations
TL;DR: It is demonstrated that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the rat, which suggests that repeated exposure to heroin produces neuroadaptative changes in brain circuits that contribute to mediate the behavioral consequences of acute administration of WIN55 212.2.
31 citations