F
Francesco Purrello
Researcher at University of Catania
Publications - 205
Citations - 5874
Francesco Purrello is an academic researcher from University of Catania. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 35, co-authored 178 publications receiving 4834 citations. Previous affiliations of Francesco Purrello include University of California, San Francisco.
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Journal ArticleDOI
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
M. Anello,Roberto Lupi,Daniela Spampinato,Salvatore Piro,Matilde Masini,Ugo Boggi,S. Del Prato,Agata Maria Rabuazzo,Francesco Purrello,Piero Marchetti +9 more
TL;DR: In pancreatic beta cells from type 2 diabetic subjects, the impaired secretory response to glucose is associated with a marked alteration of mitochondrial function and morphology, which leads to lower ATP, decreased ATP/ADP ratio, with consequent reduction of insulin release.
Journal ArticleDOI
Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease.
Luisa Spadaro,O. Magliocco,Daniela Spampinato,Salvatore Piro,C. Oliveri,C. Alagona,G. Papa,Agata Maria Rabuazzo,Francesco Purrello +8 more
TL;DR: Results indicate that alanine aminotransferase, triglyceride and serum tumour necrosis factor-alpha levels, as well as fatty liver improved after polyunsaturated fatty acid administration.
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Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: Possible role of oxidative stress
Salvatore Piro,M. Anello,Cinzia Di Pietro,Maria Natalia Lizzio,G Patanè,Agata Maria Rabuazzo,Riccardo Vigneri,Michele Purrello,Francesco Purrello +8 more
TL;DR: The data indicate that chronic exposure to elevated FFA or glucose levels increases apoptosis in rat pancreatic islets and these cytotoxic effects could be mediated by oxidative stress.
Journal ArticleDOI
A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
Piero Marchetti,Roberto Lupi,Marco Bugliani,Clare L. Kirkpatrick,Guido Sebastiani,Fabio Arturo Grieco,S Del Guerra,V. D’Aleo,Salvatore Piro,Lorella Marselli,Ugo Boggi,Franco Filipponi,Laura Tinti,Laura Salvini,Claes B. Wollheim,Francesco Purrello,Francesco Dotta +16 more
TL;DR: The presence of a functionally competent GLP-1 system in human pancreatic islets, which resides in alpha cells and might be modulated by type 2 diabetes is shown.
Journal ArticleDOI
Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition.
TL;DR: Gl glucose-induced impairment of insulin secretion is associated with altered mitochondrial function, which results in impaired glucose oxidation, overexpression of the UCP-2 protein, and a consequent decrease of ATP production in rat pancreatic islets, mediated by the PPAR-gamma pathway.