F
Francis Hickey
Researcher at University of Colorado Denver
Publications - 43
Citations - 1062
Francis Hickey is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Down syndrome & Population. The author has an hindex of 15, co-authored 38 publications receiving 807 citations. Previous affiliations of Francis Hickey include Boston Children's Hospital & Cincinnati Children's Hospital Medical Center.
Papers
More filters
Journal ArticleDOI
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation.
Kelly D. Sullivan,Donald Evans,Ahwan Pandey,Thomas Hraha,Keith P Smith,Neil E. Markham,Angela L. Rachubinski,Kristine Wolter-Warmerdam,Francis Hickey,Joaquín M. Espinosa,Joaquín M. Espinosa,Thomas Blumenthal,Thomas Blumenthal +12 more
TL;DR: Results from proteomics approaches are consistent with the hypothesis that increased interferon signaling caused by T21 leads to chronic immune dysregulation, and justify investigations to define the therapeutic value of immune-modulatory strategies in DS.
Journal ArticleDOI
Seizure frequency and characteristics in children with Down syndrome.
Hadassa Goldberg-Stern,Richard H. Strawsburg,Bonnie Patterson,Francis Hickey,Mary A. Bare,Natan Gadoth,Ton J. deGrauw +6 more
TL;DR: A regional study reinforces the relative association of seizures and Down syndrome and recommends a prospective study including a national/international registry with emphasis on developmental assessment and long-term follow up.
Journal ArticleDOI
Differences in the clinical presentation of Trisomy 21 with and without autism.
Cynthia A. Molloy,Donna S. Murray,A. Kinsman,Heidi Castillo,Terry Mitchell,Francis Hickey,Bonnie Patterson +6 more
TL;DR: Children with trisomy 21 and autism have significantly more impaired brain function than children with tr isomy 21 without autism, however, the deficits in the core domains of social reciprocity and communication, and the restricted and repetitive interests are not entirely explained by the more severe cognitive impairment.
Journal ArticleDOI
Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and down's syndrome
Yang Tang,Mark B. Schapiro,David Neal Franz,Bonnie Patterson,Francis Hickey,Elizabeth K. Schorry,Robert J. Hopkin,Matthew Wylie,Tina Narayan,Tracy A. Glauser,Donald L. Gilbert,Andrew D. Hershey,Frank R. Sharp +12 more
TL;DR: The findings suggest that blood gene expression profiling on a broader basis might be useful for genetic disease screening/diagnosis and might help elucidate mechanisms and pathways that lead to genotype–phenotype differences.
Journal ArticleDOI
Medical Update for Children With Down Syndrome for the Pediatrician and Family Practitioner
TL;DR: Down syndrome is the most common chromosomal cause of intellectual disability and requires vigilance regarding their predisposition to certain medical issues; however, after many years in caring for children with DS and their families, this experience provides continuing rewards.