F
Francis S. Willard
Researcher at Eli Lilly and Company
Publications - 97
Citations - 5904
Francis S. Willard is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Heterotrimeric G protein & G protein-coupled receptor. The author has an hindex of 39, co-authored 93 publications receiving 5249 citations. Previous affiliations of Francis S. Willard include University of North Carolina at Chapel Hill & Australian National University.
Papers
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Journal ArticleDOI
Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor
Francis S. Willard,David B. Wainscott,Aaron D. Showalter,Cynthia Stutsman,Wenzhen Ma,Guemalli R. Cardona,Richard W. Zink,Christopher M Corkins,Qi Chen,Nathan Yumibe,Javier Agejas,Graham R Cumming,José Miguel Minguez,Alma Jiménez,Ana I. Mateo,Ana M. Castaño,Daniel A. Briere,Kyle W. Sloop,Ana B. Bueno +18 more
TL;DR: In this paper, a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R) was identified, which preferentially enhances G protein-coupled signaling by the GLP1R over β-arrestin recruitment.
Journal ArticleDOI
679-P: The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes
Tamer Coskun,Julie S. Moyers,William C. Roell,Libbey S. O’Farrell,Ajit Regmi,Xiaoping Ruan,Aaron D. Showalter,Kyle W. Sloop,David B. Wainscott,Francis S. Willard,James Ficorilli,Over Cabrera,Shweta Urva,Fariba Norouziyan Cooper,Lili Guo,Jorge Alsina-Fernandez,Hongchang Qu +16 more
TL;DR: In this article, the authors characterized LY3437943, a single agent tri-agonist at the GIP, GLP-1, and glucagon (Gcg) receptors (R).
Journal ArticleDOI
Erratum: Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 15, (7066-7071) DOI: 10.1073/pnas.0912934107)
Nevin A. Lambert,Christopher A. Johnston,Steven D. Cappell,Sudhakiranmayi Kuravi,Adam J. Kimple,Francis S. Willard,David P. Siderovski +6 more
Journal ArticleDOI
RGS21, A Regulator of Taste and Mucociliary Clearance?
Adam J. Kimple,Alaina L. Garland,Staci P. Cohen,Vincent Setola,Francis S. Willard,Thomas Zielinski,Robert G. Lowery,Robert Tarran,David P. Siderovski +8 more
TL;DR: This study investigated whether regulator of G protein signaling‐21 (RGS21) has the potential to modulate signaling pathways connected to airway mucociliary clearance, given that RGS proteins modulate GPCR signaling by acting as GTPase‐accelerating proteins (GAPs) for the Gα subunits of heterotrimeric G proteins.
Book ChapterDOI
Analysis of Interactions between Regulator of G-Protein Signaling-14 and Microtubules
Luke Martin-McCaffrey,Francis S. Willard,Agnieszka Pajak,Lina Dagnino,David P. Siderovski,Sudhir J.A. D'Souza +5 more
TL;DR: Methods used for examining the impact of the RGS14/microtubule interaction in vivo and in vitro are described.