Robert Tarran

TL;DR: In CF patients with established lung disease, Pseudomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens, and in vitro studies revealed that CF-specific increases in epithelial O(2) consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection.

TL;DR: In this paper, two hypotheses, "hypotonic [low salt]/defensin" and "isotonic volume transport/mucus clearance", attempt to link defects in cystic fibrosis transmembrane conductance regulator-mediated ion transport to CF airways disease.

TL;DR: In patients with cystic fibrosis, inhalation of hypertonic saline produced a sustained acceleration of mucus clearance and improved lung function, and in vitro data suggested that sustained hydration of airway surfaces was responsible for the sustained improvement in mucus clearing.

TL;DR: How the normal coordination of opposing ion transport pathways to maintain PCL volume is disrupted in cystic fibrosis is demonstrated, the hitherto unknown role of phasic motion in regulating key aspects of normal and CF innate airways defense is discovered, and maneuvers directed at increasing motion-induced nucleotide release may be therapeutic in CF patients are demonstrated.

TL;DR: It is concluded that current knowledge of these effects is insufficient to determine whether the respiratory health effects of e-cigarette are less than those of combustible tobacco products.