Showing papers in "Journal of Hepatology in 2000"

TL;DR: The first episode of GI bleeding in patients with liver cirrhosis is associated with high morbidity and mortality, and Renal failure, rebleeding, hepatocellular carcinoma, and hepatic encephalopathy were independent risk factors for early death.

TL;DR: This article represents the final consensus document and is divided into three separate sections concerning the diagnosis, treatment and prophylaxis of SBI?

TL;DR: HCV-related disease progression is accelerated in immunocompromised compared to immunOCompetent patients, with a progressive increase in patients who have recently undergone liver transplantation.

TL;DR: In this paper, a study was conducted to correlate the occurrence and severity of liver steatosis with hepatitis C virus type, level and sequence of the core-encoding region.

TL;DR: The results of this study indicate that alcohol abuse impairs the function of the intestinal barrier, which might enhance the translocation of bacterial toxins, thereby contributing to inflammatory processes in alcoholic liver disease.

TL;DR: A series of meetings aimed at reaching consensus on the definitions of some key events related to portal hypertension and variceal bleeding and at producing guidelines for the conduct of trials in this field were held, although several issues remained unsettled.

TL;DR: HBV genotype C, compared to genotype B, is associated with a higher frequency of core promoter mutation, and a lower response rate to interferon alfa therapy.

TL;DR: Clearly, pathogenetic models have to explain the functional nature and reversibility of HE symptoms, and their precipitation by heterogeneous factors, such as infections, diuretics, sedatives, trauma, bleeding or high protein intake.

TL;DR: Recent studies suggest that early measurement of HVPG during variceal bleeding may be used as a guide for therapeutic decisions in the treatment of patients with acute varices, and the efficacy of more aggressive techniques should be further tested against beta-blockers in patients with a high risk of bleeding.

TL;DR: This work aims to provide a clear picture of the role of vaccination in the development of women’s gynecological prolapse and the importance of informed consent in the decision-making process.

TL;DR: The sensitivity of PET in diagnosis of HCC was 55% compared to 90% for CT scanning, although only PET detected some tumors (including distant metastases), and well-differentiated and low tumor grades had lower activity on PET and correspondingly lower PET scores.

TL;DR: In this paper, the role of cytotoxic T cells in the pathogenesis of hepatitis B virus (HBV) infection was investigated. And the authors showed that in the presence of an effective HBV-specific CD8 response, inhibition of virus replication can be independent of liver damage.

TL;DR: Clinically, portal vein thrombosis represents an almost pure form of portal vein obstruction; signs of liver disease are absent or transient, and the consequences for the liver are hardly discernible.

TL;DR: Terrlipressin associated with albumin appears to be a safe and effective treatment of hepatorenal syndrome.

TL;DR: It is established that the abundance of the mRNA of the main genes involved in methionine metabolism is markedly reduced in human cirrhosis and HCC, and Interestingly, MAT1A promoter was hypermethylated in the cirrhotic liver.

TL;DR: The distinction between apoptotic and necrotic cell death has become blurred recently by the recognition that the same stimuli can induce either form of cell death as well as caspase independent apoptosis.

TL;DR: In chronic hepatitis C, hypobetalipoproteinemia is prevalent and associated with steatosis, especially in patients infected with genotype 3, which suggests that HCV itself could induce hypobelipoproteineinemia and Steatosis.

TL;DR: Obese persons with higher age, with greater degrees of hepatic steatosis, and specially those with increased grades of intrahepatic inflammation have the greatest risk for progression to fibrotic liver disease.

TL;DR: The study indicates that the increased serum YKL-40 in patients with liver disease of various degree and aetiology seems to reflect fibrosis and fibrogenesis.

TL;DR: The prediction of the hepatotoxicity of new drugs must be improved, and Investigations would be particularly useful for drugs having critical chemical structures and belonging to families with an established history of hepatot toxicity.

TL;DR: It is suggested that the HEV could be more widespread than previously thought, and new evidence of the close relationship between HEV strains detected in pigs and those from acute hepatitis patients is presented.

TL;DR: The data confirm the antiviral efficacy of lamivudine in anti-HBe-positive patients, but response to a 1-year course was only transient as the majority of patients relapsed after therapy withdrawal, and therapy for chronic hepatitis B should be based on a combination of several therapeutic agents.

TL;DR: Diabetes was not associated with increased risk of rejection, retransplantation, or death at 1 year after transplantation, and had no impact on overall survival after liver transplantation.

TL;DR: In addition to antioxidants (such as PPC, silymarin, alpha-tocopherol and selenium), anti-inflammatory medications (corticosteroids, colchicine, anticytokines) are also being tested as antifibrotics.

TL;DR: Although UDCA treatment did not significantly affect time to death or liver transplantation and to clinical complications, the effects on both cholestasis and liver histology suggest that UDCA is safe and may be useful for preventing the progression of primary biliary cirrhosis.

TL;DR: Considerable progress has been made in the field of HCV since its discovery 10 years ago but a major effort needs to be made inThe next decade to control HCV-related liver disease.

TL;DR: Pre-core mutants, whose molecular pattern is strongly dependent on viral genotypes, are associated with viral persistence in anti-HBe positive patients with ongoing chronic hepatitis B.

TL;DR: Findings suggest that fatty change of small HCC is closely related to the tumor size, the histological grade and insufficient development of the arterial tumor vessels.

TL;DR: Multivariate analysis showed that five statements of the Sickness Impact Profile, related to alertness, sleep and rest, fine motor skills and work, have independent predictive power for subclinical hepatic encephalopathy.