Franck A. Atienzar

TL;DR: None of the models under study gave desirable sensitivities and a high metabolic capacity and CYP inducibility in cell lines does not necessarily correlate with a high sensitivity for the detection of hepatotoxic drugs.

TL;DR: After proper optimisation, the RAPD is a reliable, sensitive and reproducible assay, has the potential to detect a wide range of DNA damage as well as mutations and therefore can be applied to genotoxicity and carcinogenesis studies and is suggested that these assays would continue to complement the use of emerging technologies.

TL;DR: Not only was the RAPD profiling method shown to be a rapid and reproducible assay of toxicant—induced DNA effects, but the qualitative measure of genomic template stability compared favorably with the traditional indices of fitness.

TL;DR: The random amplified polymorphic DNA (RAPD) assay and related techniques like the arbitrarily primed polymerase chain reaction (AP-PCR) have been shown to detect genotoxin-induced DNA damage and mutations but further research is required to better understand the potential and limitations of the RAPD assay.

TL;DR: The RAPD method, used to detect DNA damage in the sublittoral macroalgae Palmaria palmata (Rhodophyta) exposed to both ambient and elevated irradiances of UV-B, may prove to be a valuable tool for investigating the specific effects of genotoxic agents upon marine algal populations.