H
Helga Gerets
Researcher at UCB
Publications - 16
Citations - 986
Helga Gerets is an academic researcher from UCB. The author has contributed to research in topics: In vivo & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 850 citations.
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Journal ArticleDOI
Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.
Helga Gerets,K. Tilmant,Brigitte Gerin,H. Chanteux,B. O. Depelchin,Stephane Dhalluin,Franck A. Atienzar +6 more
TL;DR: None of the models under study gave desirable sensitivities and a high metabolic capacity and CYP inducibility in cell lines does not necessarily correlate with a high sensitivity for the detection of hepatotoxic drugs.
Journal ArticleDOI
The use of real-time cell analyzer technology in drug discovery: defining optimal cell culture conditions and assay reproducibility with different adherent cellular models.
Franck A. Atienzar,K. Tilmant,Helga Gerets,Gaelle Toussaint,Sebastien Speeckaert,Etienne Hanon,Olympe Depelchin,Stephane Dhalluin +7 more
TL;DR: The RTCA technology appears to be a powerful and reliable tool in drug discovery because of the reasonable throughput, rapid and efficient performance, technical optimization, and cell quality control.
Journal ArticleDOI
Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach.
Helga Gerets,Etienne Hanon,Miranda Cornet,Stephane Dhalluin,Olympe Depelchin,Michael Canning,Franck A. Atienzar +6 more
TL;DR: The data indicated that the potential of this battery of selected assays measured in a multiplex format not only made it possible to rank and select the most promising drug candidates based on their cytotoxic potential, but also to gather information that may help to understand some of the toxic events occurring in the cells.
Journal ArticleDOI
Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans
Franck A. Atienzar,Eric Novik,Helga Gerets,Amit Parekh,Claude Delatour,Alvaro Cardenas,James S. MacDonald,Martin L. Yarmush,Stephane Dhalluin +8 more
TL;DR: The development of a co-culture dog model for predicting hepatotoxic drugs in humans and to compare the predictivity of the canine model along with primary human hepatocytes and HepG2 cells are described.
Journal ArticleDOI
Evaluation of Impedance-Based Label-Free Technology as a Tool for Pharmacology and Toxicology Investigations
TL;DR: The objective of the present study was to further assess the usefulness of the real-time cell analyzer (RTCA) and, in particular, the xCELLigence platform, in the context of early drug development for pharmacology and toxicology investigations.