F
Franck Kalume
Researcher at Seattle Children's Research Institute
Publications - 32
Citations - 3066
Franck Kalume is an academic researcher from Seattle Children's Research Institute. The author has contributed to research in topics: Epilepsy & Dravet syndrome. The author has an hindex of 15, co-authored 30 publications receiving 2623 citations. Previous affiliations of Franck Kalume include University of Tennessee & University of California, San Francisco.
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Journal ArticleDOI
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
Frank H. Yu,Massimo Mantegazza,Ruth E. Westenbroek,Carol A. Robbins,Franck Kalume,Kimberly A. Burton,William J. Spain,G. Stanley McKnight,Todd Scheuer,William A. Catterall +9 more
TL;DR: The results indicate that reduced sodium currents in GABAergic inhibitory interneurons in Scn1a+/− heterozygotes may cause the hyperexcitability that leads to epilepsy in patients with SMEI.
Journal ArticleDOI
NaV1.1 channels and epilepsy
TL;DR: A unified loss‐of‐function hypothesis for the spectrum of epilepsy syndromes caused by genetic changes in NaV1.1 channels is proposed, in which mild impairment predisposes to febrile seizures, intermediate impairment leads to GEFS+ epilepsy, and severe or complete loss of function leads to the intractable seizures and comorbidities of SMEI.
Journal ArticleDOI
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome
Christine S. Cheah,Frank H. Yu,Ruth E. Westenbroek,Franck Kalume,John C. Oakley,Gregory B. Potter,John L.R. Rubenstein,William A. Catterall +7 more
TL;DR: Immunocytochemical studies demonstrated selective loss of NaV1.1 channels in forebrain GABAergic neurons is both necessary and sufficient to cause epilepsy and premature death in DS.
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Autoimmunity due to molecular mimicry as a cause of neurological disease
Michael C. Levin,Michael C. Levin,Sangmin Lee,Franck Kalume,Yvette Morcos,F. Curtis Dohan,Karen A. Hasty,Karen A. Hasty,Joseph C. Callaway,Joseph R. Zunt,Dominic M. Desiderio,John M. Stuart,John M. Stuart +12 more
TL;DR: This study establishes a clear link between viral infection, autoimmunity and neurological disease in humans and demonstrates the importance of molecular mimicry between an infecting agent and hnRNP-A1 in autoimmune disease of the CNS.
Journal ArticleDOI
Reduced Sodium Current in Purkinje Neurons from NaV1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in Infancy
TL;DR: Results show that NaV1.1 channels play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent, and resurgent forms of sodium current and to sustained action potential firing.