Franco Valenza

TL;DR: The concept that mechanical ventilation can have a significant influence on the inflammatory/anti-inflammatory milieu of the lung, and thus play a role in initiating or propagating a local, and possibly systemic inflammatory response, is supported.

TL;DR: Plateau pressure and tidal volume are inadequate surrogates for lung stress and strain according to the functional residual capacity variability.

TL;DR: The distribution of tidal volume (VT) and recruitment was investigated by chest computed tomography (CT) in eight sedated-paralyzed patients with the adult respiratory distress syndrome (ARDS) and found that with increasing PEEP, the VTct distribution decreased significantly in the upper levels, did not change in the middle levels, and increased significantly (p < 0.01) in the lower levels.

TL;DR: B baseline Cst,w and its changes may play a role in determining the oxygenation response in the prone position; (2) theprone position improves CSt,rs and CST,L when the supine position is resumed.

TL;DR: The time is now right to apply the knowledge obtained with Pes to improve the management of critically ill and ventilator-dependent patients, as Pes measurements have enhanced the understanding of the pathophysiology of acute lung injury, patient-ventilator interaction, and weaning failure.