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Arthur S. Slutsky
Researcher at University of Toronto
Publications - 653
Citations - 88567
Arthur S. Slutsky is an academic researcher from University of Toronto. The author has contributed to research in topics: Lung injury & Mechanical ventilation. The author has an hindex of 117, co-authored 610 publications receiving 73092 citations. Previous affiliations of Arthur S. Slutsky include Beth Israel Deaconess Medical Center & Toronto General Hospital.
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Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries
Giacomo Bellani,John G. Laffey,John G. Laffey,Tài Pham,Tài Pham,Eddy Fan,Eddy Fan,Laurent Brochard,Laurent Brochard,Andrés Esteban,Luciano Gattinoni,Frank van Haren,Anders Larsson,Daniel F. McAuley,Marco Ranieri,Gordon D. Rubenfeld,Gordon D. Rubenfeld,B. Taylor Thompson,Hermann Wrigge,Arthur S. Slutsky,Antonio Pesenti +20 more
TL;DR: Clinician recognition of ARDS was associated with higher PEEP, greater use of neuromuscular blockade, and prone positioning, which indicates the potential for improvement in the management of patients with ARDS.
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Keiji Kuba,Yumiko Imai,Shuan Rao,Hong Gao,Feng Guo,Bin Guan,Yi Huan,Peng Yang,Yanli Zhang,Wei Deng,Linlin Bao,Binlin Zhang,Guang Liu,Zhong Wang,Mark C. Chappell,Yanxin Liu,Dexian Zheng,Andreas Leibbrandt,Teiji Wada,Arthur S. Slutsky,Depei Liu,Chuan Qin,Chengyu Jiang,Josef M. Penninger +23 more
TL;DR: A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.
Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Yumiko Imai,Keiji Kuba,Shuan Rao,Yi Huan,Feng Guo,Bin Guan,Peng Yang,Renu Sarao,Teiji Wada,Howard Leong-Poi,Michael A. Crackower,Akiyoshi Fukamizu,Chi-chung Hui,Lutz Hein,Stefan Uhlig,Arthur S. Slutsky,Chengyu Jiang,Josef M. Penninger +17 more
TL;DR: It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
Journal ArticleDOI
Functional disability 5 years after acute respiratory distress syndrome.
Margaret S. Herridge,Catherine M. Tansey,Andrea Matte,George Tomlinson,Natalia Diaz-Granados,Andrew B. Cooper,Cameron B. Guest,C. D. Mazer,Sangeeta Mehta,Thomas E. Stewart,Paul Kudlow,Deborah J. Cook,Arthur S. Slutsky,Angela M. Cheung +13 more
TL;DR: Exercise limitation, physical and psychological sequelae, decreased physical quality of life, and increased costs and use of health care services are important legacies of severe lung injury.