F
François Berthou
Researcher at French Institute of Health and Medical Research
Publications - 74
Citations - 4098
François Berthou is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hydroxylation & Cytochrome P450. The author has an hindex of 38, co-authored 74 publications receiving 3992 citations. Previous affiliations of François Berthou include European University of Brittany & University of Western Brittany.
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Journal ArticleDOI
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.
Christelle Iribarne,François Berthou,Susan Baird,Yvonne Dréano,Daniel Picart,Jean-Pierre Bail,Philippe Beaune,Jean François Ménez +7 more
TL;DR: It can be asserted that P450 3A4 is the major enzyme involved in the N-demethylation of methadone on average, and caution should be advised in the clinical use of methamphetamineadone when other drugs are also administered that induce or inhibit P4503A4, such as rifampicin or diazepam.
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Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes.
TL;DR: In vitro observations establish that a P450 enzyme of the IIIA sub-family is involved in the oxidative demethylation of tamoxifen in human liver.
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Metabolism of eicosapentaenoic and docosahexaenoic acids by recombinant human cytochromes P450.
Maude Fer,Yvonne Dréano,Danièle Lucas,Laurent Corcos,Jean-Pierre Salaün,François Berthou,Yolande Amet +6 more
TL;DR: It is demonstrated that other polyunsaturated long-chain fatty acids (PUFA-LC), especially the omega3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA), are also epoxidised.
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Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
TL;DR: Investigation of the inhibitory effect of RESV on CYP1A, CYP2E1 and CYP3A enzymatic activities and that of non volatile compounds present in red wine found that RSW inhibitoryEffect was not only due to RESV, but also to other compounds whose identification would prove to be worthwhile because of their possible chemopreventive properties.
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Involvement of cytochrome p450 3a4 in n-dealkylation of buprenorphine in human liver microsomes
TL;DR: Data demonstrate that P450 3A4 is the major enzyme involved in hepatic buprenorphine N-dealkylation, which is a long acting analgesic of the opiate family.