François Bonneaux

TL;DR: Study of the effect of several biocompatible solvents with different physico-chemical properties on the release of ivermectin (IVM), an antiparasitic BCS II drug from in situ forming PLA-based implants found a relationship between the rate of IVM release and the surface porosity of the implants, release being higher as implant porosity increased.

TL;DR: This study has shown that the phagocytic circulating cells involved in the nanoparticle uptake were mainly neutrophilic granulocytes and some of them were found in the spleen.

TL;DR: Taking into account their oxygen-binding characteristics, the low-molecular-weight conjugates can be regarded as potential erythrocyte substitutes and seem to be due to modification of amine groups involved in the salt bridges that stabilize the deoxy form of the protein.

TL;DR: The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was investigated and the effect of polymer concentration in emulsion on particle size and surface coverage was examined.

TL;DR: The polyanionic polymers were shown to act as macromolecular effectors: in fact they bind to the liganded haemoglobin by means of a large number of relatively weak sites, whereas they strongly Bind to the unliganded protein by meansof a tight interaction inside the diphosphoglycerate binding cavity.