F
François Denis
Researcher at University of Lausanne
Publications - 4
Citations - 894
François Denis is an academic researcher from University of Lausanne. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 4, co-authored 4 publications receiving 890 citations.
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Journal ArticleDOI
Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.
Giuseppe Pantaleo,James F. Demarest,H Soudeyns,Cecilia Graziosi,François Denis,Joseph W. Adelsberger,Persephone Borrow,Michael S. Saag,George M. Shaw,Rafick Pierre Sekaly,Rafick Pierre Sekaly +10 more
TL;DR: Major oligoclonal expansions of these CD8+ T lymphocytes may represent an important component of the primary immune response to viral infections and may help to clarify both the immunopathogenic and the protective mechanisms of HIV infection.
Journal ArticleDOI
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection
Giuseppe Pantaleo,Hugo Soudeyns,James F. Demarest,Mauro Vaccarezza,Cecilia Graziosi,Stefania Paolucci,Marybeth Daucher,Oren J. Cohen,François Denis,William E. Biddison,Rafick Pierre Sekaly,Anthony S. Fauci +11 more
TL;DR: This analysis demonstrated that a significant number of HIV-specific T cell clones involved in the primary immune response rapidly disappeared, and this should provide insights into how HIV, and possibly other viruses, elude the host immune response during primary infection.
Journal ArticleDOI
Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.
Giuseppe Pantaleo,Hugo Soudeyns,Hugo Soudeyns,James F. Demarest,Mauro Vaccarezza,Cecilia Graziosi,Stefania Paolucci,Marybeth Daucher,Oren J. Cohen,François Denis,William E. Biddison,Rafick Pierre Sekaly,Rafick Pierre Sekaly,Anthony S. Fauci +13 more
TL;DR: It was shown that HIV‐specific CTL clones preferentially accumulated in blood as opposed to lymph node, which should provide new insights into how HIV, and possibly other viruses, elude the immune response of the host during primary infection.