L
Loreley Calvet
Publications - 15
Citations - 724
Loreley Calvet is an academic researcher. The author has contributed to research in topics: Cancer research & YAP1. The author has an hindex of 7, co-authored 11 publications receiving 637 citations.
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Journal ArticleDOI
Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
Sylvia Julien,Ana Merino-Trigo,Ludovic Lacroix,Marc Pocard,Diane Goéré,Pascale Mariani,Sophie Landron,Ludovic Bigot,Fariba Nemati,Peggy Dartigues,Louis-Bastien Weiswald,Denis Lantuas,Loïc Morgand,Emmanuel Pham,Patrick Gonin,Virginie Dangles-Marie,Bastien Job,Philippe Dessen,Alain Bruno,Alain Pierré,Hany Soliman,Manoel Nunes,Guillaume Lardier,Loreley Calvet,Brigitte Demers,Gregoire Prevost,Patricia Vrignaud,Sergio Roman-Roman,Olivier Duchamp,Cyril Berthet +29 more
TL;DR: An extensive in vivo analysis of patient-derived xenograft models for CRC shows the loss of human stroma cells after engraftment, observed a metastatic phenotype in some models, and compared the molecular profile with the drug sensitivity of each tumor model.
Journal ArticleDOI
Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Patricia Vrignaud,Dorothée Semiond,Pascale Lejeune,Herve Bouchard,Loreley Calvet,Cecile Combeau,Jean-François Riou,Alain Commercon,François Lavelle,Marie-Christine Bissery +9 more
TL;DR: Cabazitaxel is as active as docetaxel in docentaxel-sensitive tumor models but is more potent than docetAXel in tumor models with innate or acquired resistance to taxanes and other chemotherapies.
Journal ArticleDOI
A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility
Loredana Vecchione,Valentina Gambino,Jonne A. Raaijmakers,Andreas Schlicker,Arianna Fumagalli,Mariangela Russo,Alberto Villanueva,Evelyne Beerling,Alice Bartolini,David G. Molleví,Nizar El-Murr,Marielle Chiron,Loreley Calvet,Céline Nicolazzi,Cecile Combeau,Christophe Henry,Iris Simon,Sun Tian,Sjors G J G In 't Veld,Giovanni D'Ario,Sara Mainardi,Roderick L. Beijersbergen,Cor Lieftink,Sabine C. Linn,Cornelia Rumpf-Kienzl,Mauro Delorenzi,Mauro Delorenzi,Lodewyk F. A. Wessels,Ramon Salazar,Federica Di Nicolantonio,Alberto Bardelli,Jacco van Rheenen,René H. Medema,Sabine Tejpar,René Bernards +34 more
TL;DR: It is found that BRAF-like CCs display far greater sensitivity to the microtubule poison vinorelbine both in vitro and in vivo, suggesting that vinORElbine is a potential tailored treatment for BRAF/V600E CCs.
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Production of the Bengamide Class of Marine Natural Products in Myxobacteria: Biosynthesis and Structure-Activity Relationships.
Silke C. Wenzel,Holger Hoffmann,Jidong Zhang,Laurent Debussche,Sabine Haag-Richter,Michael Kurz,Frederico Nardi,Peer Lukat,Irene Kochems,Tietgen Heiko,Dietmar Schummer,Jean-Paul Nicolas,Loreley Calvet,Valerie Czepczor,Patricia Vrignaud,Agnes Mühlenweg,Stefan Pelzer,Rolf Müller,Mark Brönstrup +18 more
TL;DR: A combination of semisynthesis of microbially derived bengamides and total synthesis resulted in an optimized derivative that combined high cellular potency in the nanomolar range with high metabolic stability, which translated to an improved half-life in mice and antitumor efficacy in a melanoma mouse model.
Journal ArticleDOI
The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET-Amplified Cancer
Coumaran Egile,Mireille Kenigsberg,Christine Delaisi,Françoise Bégassat,Véronique Do-Vale,Jessica Mestadier,Fabrice Bonche,Tsiala Benard,Jean-Paul Nicolas,Sandrine Valence,Celine Lefranc,Elisa Francesconi,Christelle Castell,Anne-Marie Lefebvre,Conception Nemecek,Loreley Calvet,Hélène Goulaouic +16 more
TL;DR: It is demonstrated that SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile, supporting its clinical development in patients with MET-amplified and MET pathway–addicted tumors.