There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis In addition to their efficiency and practicality, mechanochemical reactions are also recognized for their sustainability The association between mechanochemistry and Green Chemistry often originates from the solvent-free nature of most mechanochemical protocols, which can reduce waste production However, mechanochemistry satisfies more than one of the Principles of Green Chemistry In this Review we will present a series of examples that will clearly illustrate how mechanochemistry can significantly contribute to the fulfillment of Green Chemistry in a more holistic manner

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry.

The extraordinary impact of metal-based complexes on synthetic methods is still recognized nowadays, and attempts are currently undertaken to further extend the use of metal-assisted chemistry to e...

Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions

Novel transition metal complexes of nickel(II), copper(II) and zinc(II) with a symmetrical tetradentate Schiff base, obtained by condensation of 1,3-diaminopropane and 3,5-diiodosalicylaldehyde, N,N′-bis(3,5-diiodosalicylaldehyde)-1,3-diaminoporpane (H2L), have been prepared and characterized by elemental (CHN), FT-IR, UV–Vis and 1H NMR spectroscopic techniques. Out of these, copper (Cu(L)) and zinc (Zn(L)) complexes were isolated in the form of single crystals and characterized by single-crystal X-ray diffraction studies. In the Cu(L) complex, the geometry was found to be slightly distorted square planar, whereas the Zn(L) complex adapted slightly distorted octahedral geometry due to the attachment of two pyridine rings. The antibacterial screening of the prepared compounds was carried out by taking two Gram-positive (Staphylococcus aureus and Bacillus cereus) and two Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial strains. The appearance of zones of inhibition clearly depicted that the complexes have more retardation potential as compared to the Schiff base ligand.

Nickel(II), copper(II) and zinc(II) complexes containing symmetrical Tetradentate Schiff base ligand derived from 3,5-diiodosalicylaldehyde: Synthesis, characterization, crystal structure and antimicrobial activity

Mechanosynthesis is a powerful alternative to traditional solvent-based synthesis as it allows for higher yields in shorter reaction times, while minimizing the use of solvents. Although mechanoche...

Multigram Mechanochemical synthesis of a Salophen Complex: A Comparative Analysis

https://hal.archives-ouvertes.fr/hal-03103305/document

Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1,2-bicyclo[2.2.2]octane bridge

The use of ball-mills enabled the straightforward synthesis of a variety of silver(I) complexes featuring challenging NHC ligands. Sterically hindered including electron-poor or with very low solubility imidazolium salts were grinded with silver(I) oxide to furnish heteroleptic or homoleptic complexes in high yield and short reaction times. The synthesis of heteroleptic bis-NHC silver(I) complexes was also performed for the first time in a ball-mill. The efficiency and rapidity of the mechanochemical approach enabled the generation of a library of unprecedented NHC silver complexes, which cytotoxicity on HCT116 colorectal cancer cell line was evaluated providing a rare example of medicinal mechanochemistry. The cationic silver complexes were found more potent than the neutral analogues, with IC50 values down to 21 nM, 256 times more potent than cisplatin.

https://hal-normandie-univ.archives-ouvertes.fr/hal-02919846/document

Solving the challenging synthesis of highly cytotoxic silver complexes bearing sterically hindered NHC ligands with mechanochemistry.

https://hal.umontpellier.fr/hal-02519408/document

François Quintin

Papers

Synthesis, characterisation and cytotoxic activity evaluation of new metal-salen complexes based on the 1,2-bicyclo[2.2.2]octane bridge

Solving the challenging synthesis of highly cytotoxic silver complexes bearing sterically hindered NHC ligands with mechanochemistry.

Mechanosynthesis of Noels-type NHC–Ruthenium Complexes and Applications in Ring-Opening Metathesis Polymerization