Frank Boellmann

TL;DR: It is shown that CHIP not only enhances Hsp70 induction during acute stress but also mediates its turnover during the stress recovery process, providing an elegant mechanism for maintaining homeostasis by tuning chaperone levels appropriately to reflect the status of protein folding within the cytoplasm.

TL;DR: The heat shock protein response appears to be triggered primarily by nonnative proteins accumulating in a stressed cell and results in increased expression of heat shock proteins (HSPs), and HSPs and co-chaperone complexes regulate HSF1 activity at different levels.

TL;DR: In this paper, metabolic clearance and plasma protein binding were used to parameterize a population-based in vitro-to-in vivo extrapolation model for estimating the human oral equivalent dose necessary to produce a steady-state in vivo concentration equivalent to in vitro AC50 (concentration at 50% of maximum activity) and LEC (lowest effective concentration).

TL;DR: The results suggest that differential methylation following As treatment may only play a permissive role in regulating expression, and the subset of 17 genes that showed an inverse relationship between As-related methylation and expression included a substantial number that has been demonstrated to play a functional role in cancer-related processes.

TL;DR: Improvements and further refinements of the latter gene switches are reviewed as well as uses of these gene switches in research and experimental therapy are exemplified.