C
Cam Patterson
Researcher at University of North Carolina at Chapel Hill
Publications - 201
Citations - 18436
Cam Patterson is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 68, co-authored 200 publications receiving 17410 citations. Previous affiliations of Cam Patterson include NewYork–Presbyterian Hospital.
Papers
More filters
Journal ArticleDOI
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
TL;DR: It is shown that CHIP functions with Hsc70 to sense the folded state of CFTR and targets aberrant forms for proteasomal degradation by promoting their ubiquitination.
Journal ArticleDOI
The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.
Brian A. Clarke,Doreen Drujan,Monte S. Willis,Leon Murphy,Richard A. Corpina,Elena Burova,Sergey V. Rakhilin,Trevor Stitt,Cam Patterson,Esther Latres,David J. Glass +10 more
TL;DR: The mechanism by which MYH is depleted under atrophy conditions is identified and it is demonstrated that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein.
Journal ArticleDOI
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
Chad A. Dickey,Chad A. Dickey,Adeela Kamal,Karen Lundgren,Natalia Klosak,Rachel M. Bailey,Judith Dunmore,Peter E.A. Ash,Sareh Shoraka,Jelena Zlatkovic,Christopher B. Eckman,Cam Patterson,Dennis W. Dickson,N. Stanley Nahman,Mike Hutton,Francis Burrows,Leonard Petrucelli +16 more
TL;DR: It is reported that inhibition of Hsp90 led to decreases in p-tau levels independent of heat shock factor 1 (HSF1) activation, and this is the first demonstration to the authors' knowledge that blockade of the refolding pathway promotes p-Tau turnover through degradation.
Journal ArticleDOI
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Jian-Fu Chen,Elizabeth P. Murchison,Ruhang Tang,Thomas E. Callis,Mariko Tatsuguchi,Zhongliang Deng,Mauricio Rojas,Scott Hammond,Michael D. Schneider,Craig H. Selzman,Gerhard Meissner,Cam Patterson,Gregory J. Hannon,Da-Zhi Wang +13 more
TL;DR: It is reported that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM, heart failure, and postnatal lethality and indicates that miRNAs play critical roles in normal cardiac function and under pathological conditions.
Journal ArticleDOI
p47phox is required for atherosclerotic lesion progression in ApoE–/– mice
Patricia A. Barry-Lane,Cam Patterson,Marie van der Merwe,Zhaoyong Hu,Stephen M. Holland,Edward T.H. Yeh,Marschall S. Runge +6 more
TL;DR: These studies provide convincing support for the hypothesis that superoxide generation in general, and NADPH oxidase in particular, have a requisite role in atherosclerotic lesion formation, and they provide a rationale for further studies to dissect the contributions of ROS to vascular lesions formation.