F
Frank G. Guarnieri
Researcher at Johns Hopkins University
Publications - 8
Citations - 1889
Frank G. Guarnieri is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Antigen & Major histocompatibility complex. The author has an hindex of 7, co-authored 7 publications receiving 1825 citations.
Papers
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Journal Article
Treatment of Established Tumors with a Novel Vaccine That Enhances Major Histocompatibility Class II Presentation of Tumor Antigen
Ken Yu Lin,Frank G. Guarnieri,Kevin Staveley-O'Carroll,Hyam I. Levitsky,J. Thomas August,Drew M. Pardoll,Tzyy Choou Wu +6 more
TL;DR: It is demonstrated that modifications that reroute a cytosolic tumor antigen to the endosomal/lysosomal compartment can profoundly improve the in vivo therapeutic potency of recombinant vaccines.
Journal ArticleDOI
Engineering an intracellular pathway for major histocompatibility complex class ii presentation of antigens
Tzyy Choou Wu,Frank G. Guarnieri,Kevin Staveley-O'Carroll,Raphael P. Viscidi,Hyam I. Levitsky,Lora Hedrick,Kathleen R. Cho,J. T. August,Drew M. Pardoll +8 more
TL;DR: In vivo immunization experiments in mice demonstrated that vaccinia containing the chimeric E7/LAMP-1 gene generated greater E7-specific lymphoproliferative activity, antibody titers, and cytotoxic T-lymphocyte activities than vacciniacontaining the wild-type HPV-16 E7 gene.
Journal Article
Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity
Hyam I. Levitsky,Jami Montgomery,Mojgan Ahmadzadeh,Kevin Staveley-O'Carroll,Frank G. Guarnieri,Dan L. Longo,Larry W. Kwak +6 more
TL;DR: This is the first demonstration that T cell responses specific for a native tumor Ag are generated by GM-CSF-transduced tumor cell-based vaccination, suggesting that B cell lymphoma may be a suitable disease for genetically modified tumor vaccine strategies.
Journal Article
Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells
J. F. Rowell,A. L. Ruff,Frank G. Guarnieri,Kevin Staveley-O'Carroll,Xinli Lin,J. Tang,J. T. August,Robert F. Siliciano +7 more
TL;DR: The proliferative response of env-specific CD4+ T cell clones to the env-LAMP-1 chimera was greatly enhanced compared with wild-type env protein, especially when limiting numbers of stimulator cells were used and the enhanced stimulatory capacity of APC expressing LAMP- 1-targeted Ags has important implications for vaccine design.
Patent
Lysosomal targeting of immunogens
TL;DR: In this paper, the authors proposed a targeting signal that will direct proteins to the endosomal/lysosomal compartment, where the antigenic domain is processed and peptides from it are presented on the cell surface in association with major histocompatibility (MHC) class II molecules.