K
Ken Yu Lin
Researcher at University of Texas Southwestern Medical Center
Publications - 25
Citations - 2235
Ken Yu Lin is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Immunotherapy & Ovarian cancer. The author has an hindex of 19, co-authored 23 publications receiving 2086 citations. Previous affiliations of Ken Yu Lin include Chang Gung University & Johns Hopkins University.
Papers
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Journal Article
Treatment of Established Tumors with a Novel Vaccine That Enhances Major Histocompatibility Class II Presentation of Tumor Antigen
Ken Yu Lin,Frank G. Guarnieri,Kevin Staveley-O'Carroll,Hyam I. Levitsky,J. Thomas August,Drew M. Pardoll,Tzyy Choou Wu +6 more
TL;DR: It is demonstrated that modifications that reroute a cytosolic tumor antigen to the endosomal/lysosomal compartment can profoundly improve the in vivo therapeutic potency of recombinant vaccines.
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Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors.
Hongxiu Ji,Tian Li Wang,Chien Hung Chen,Chien Hung Chen,Sara I. Pai,Chien Fu Hung,Ken Yu Lin,Robert J. Kurman,Drew M. Pardoll,Tzyy Choou Wu +9 more
TL;DR: Results indicate that linkage of the antigen gene to an endosomal/lysosomal targeting signal may greatly enhance the potency of DNA vaccines.
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Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein.
TL;DR: The data suggest that the Sig/E7/LAMP‐1 vaccine is effective in controlling the hematogenous spread of TC‐1 tumor cells.
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Cell Surface-Binding Motifs of L2 That Facilitate Papillomavirus Infection
TL;DR: Mutation of L2 residues 18 and 19 or 21 and 22 significantly reduces both the ability of the HPV16 L2 13-31-GFP fusion protein to bind to SiHa cells and the infectivity of HPV16 pseudovirions.
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Perspectives for Preventive and Therapeutic HPV Vaccines
TL;DR: Current preventive and therapeutic HPV vaccines and their future directions are discussed, which aim to generate a cell-mediated immune response to infected cells.