F
Frank Möhrlen
Researcher at Heidelberg University
Publications - 45
Citations - 1385
Frank Möhrlen is an academic researcher from Heidelberg University. The author has contributed to research in topics: Olfactory receptor & Chloride channel. The author has an hindex of 21, co-authored 45 publications receiving 1270 citations.
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Journal ArticleDOI
The proteome of rat olfactory sensory cilia
Ulrich Mayer,Alexander Küller,Philipp Daiber,Inge Neudorf,Uwe Warnken,Martina Schnölzer,Stephan Frings,Frank Möhrlen +7 more
TL;DR: Organellar proteomics yielded decisive information about the diverse physiological functions of a sensory organelle about which more than 80% can be attributed to the characteristic functions of olfactory sensory neurons and their cilia: signal processing, protein targeting, neurogenesis, solute transport, and cytoprotection.
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Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons
Katharina Funk,Anne Woitecki,Christina Franjic-Würtz,Thomas Gensch,Frank Möhrlen,Stephan Frings +5 more
TL;DR: A fundamental transition in Cl- homeostasis toward a state of augmented Cl- accumulation is induced by a 1–3 hour treatment with inflammatory mediators, which corroborate current concepts for the role of Cl- regulation in the generation of inflammatory hyperalgesia and allodynia.
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Molecular components of signal amplification in olfactory sensory cilia
TL;DR: A specific set of ciliary proteins involved in anion-based signal amplification is described, providing a molecular concept for the unique strategy that allows olfactory sensory neurons to operate as efficient transducers of weak sensory stimuli.
Journal ArticleDOI
Differential maturation of chloride homeostasis in primary afferent neurons of the somatosensory system.
Daniel Gilbert,Christina Franjic-Würtz,Katharina Funk,Thomas Gensch,Stephan Frings,Frank Möhrlen +5 more
TL;DR: It is found that the somatosensory neurons undergo a transition of Cl− homeostasis during the first three postnatal weeks that leads to a decline of [Cl−]i in most neurons.
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An evolutionary conserved role of Wnt signaling in stem cell fate decision.
TL;DR: An ancient role of Wnt signaling in stem cell fate determination is suggested in Hydractinia, a member of the ancient metazoan phylum Cnidaria by analyzing two key molecules in this pathway, frizzled and ss-catenin, and blocking GSK-3.