S
Stephan Frings
Researcher at Heidelberg University
Publications - 114
Citations - 5202
Stephan Frings is an academic researcher from Heidelberg University. The author has contributed to research in topics: Cyclic nucleotide-gated ion channel & Olfactory receptor. The author has an hindex of 39, co-authored 114 publications receiving 4983 citations. Previous affiliations of Stephan Frings include Saarland University & Johns Hopkins University.
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Journal ArticleDOI
Cloning and functional expression of a cyclic-nucleotide-gated channel from mammalian sperm
Ingo Weyand,Matthias Godde,Stephan Frings,J Weiner,Frank Müller,W. Altenhofen,Hanns Hatt,U B Kaupp +7 more
TL;DR: The cloning and functional expression of a novel CNG channel from bovine testis was functionally localized in sperm, but is also specifically expressed in cone photoreceptor cells, and might be involved in chemotaxis of sperm by controlling Ca2+ entry through a cyclic-nucleotide signalling pathway.
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The Native Rat Olfactory Cyclic Nucleotide-Gated Channel Is Composed of Three Distinct Subunits
Wolfgang Bönigk,Jonathan Bradley,Frank Müller,Federico Sesti,Ingrid Boekhoff,Gabriele V. Ronnett,U. Benjamin Kaupp,Stephan Frings +7 more
TL;DR: It is concluded that the native CNG channel in OSNs is composed of all three subunits, and that CNG channels in both rod photoreceptors and olfactory sensory neurons result from coassembly of specific α subunits with various forms of an alternatively spliced β subunit.
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Profoundly Different Calcium Permeation and Blockage Determine the Specific Function of Distinct Cyclic Nucleotide-Gated Channels
TL;DR: Cloned CNG channels from photoreceptors and olfactory sensory neurons profoundly differ in their relative Ca2+ permeability, their blocking by external divalent cations, and the fraction of current carried by Ca2+.
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Neuronal Ca2+-activated Cl− channels — homing in on an elusive channel species
TL;DR: This review collects results both from neuronal and from non-neuronal cells with the intent of facilitating research into Ca2+ -activated Cl- channels and their physiological functions in neurons.
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Properties of Cyclic Nucleotide-gated Channels Mediating Olfactory Transduction Activation, Selectivity, and Blockage
TL;DR: In this paper, the authors investigated properties of cyclic nucleotide-gated channels (cng channels) from frog and rat using inside-out and outside-out membrane patches excised from isolated olfactory receptor cells.