F
Frank Musshoff
Researcher at University of Bonn
Publications - 194
Citations - 6538
Frank Musshoff is an academic researcher from University of Bonn. The author has contributed to research in topics: Poison control & Hair analysis. The author has an hindex of 40, co-authored 184 publications receiving 5914 citations. Previous affiliations of Frank Musshoff include American Board of Legal Medicine.
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Validation of new methods.
TL;DR: Important considerations in analytical method validation will be discussed and may be used as guidance by scientists wishing to develop and validate analytical methods.
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Concentrations of Tramadol and O-desmethyltramadol Enantiomers in Different CYP2D6 Genotypes
TL;DR: YP2D6 genotype determined concentrations of O‐desmethyltramadol enantiomers and influenced efficacy of tramadol treatment and in PMs, non‐response rates to tramadols treatment increased fourfold compared with the other genotypes.
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Review of biologic matrices (urine, blood, hair) as indicators of recent or ongoing cannabis use.
Frank Musshoff,Burkhard Madea +1 more
TL;DR: The cannabis influence factor was demonstrated as a better tool to interpret the concentrations of THC and its metabolites in blood in forensic cases and therefore it was proposed to assume absolute driving inability because of cannabis intoxication from a CIF ≥10.
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Respiratory Depression with Tramadol in a Patient with Renal Impairment and CYP2D6 Gene Duplication
TL;DR: Analysis of the patient's genotype revealed a CYP2D6 gene duplication resulting in ultra-rapid metabolism of tramadol to its active metabolite (+)O-desmethyltramadol, which should be a future diagnostic target whenever administration of Tramadol or codeine is anticipated, as both drugs are subject to a comparable CYP 2D6-dependent metabolism.
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New trends in hair analysis and scientific demands on validation and technical notes.
Frank Musshoff,Burkhard Madea +1 more
TL;DR: This review focuses on basic aspects of method development and validation of hair testing procedures, namely mechanisms of drug incorporation and retention, novel analytical procedures, and the determination of THC-COOH in hair samples.