Journal ArticleDOI
Validation of new methods.
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TLDR
Important considerations in analytical method validation will be discussed and may be used as guidance by scientists wishing to develop and validate analytical methods.About:
This article is published in Forensic Science International.The article was published on 2007-01-17. It has received 1157 citations till now. The article focuses on the topics: Analytical Toxicology.read more
Citations
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Society of Hair Testing guidelines for drug testing in hair
TL;DR: The Society of Hair Testing Guidelines for Drug Testing in Hair provide laboratories with recommended best practice guidelines whether they are currently offering drug testing in hair, or plan to offer a hair testing service in the future.
Journal ArticleDOI
Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference.
Pierre Wallemacq,Victor W. Armstrong,Mercè Brunet,Vincent Haufroid,David W. Holt,Atholl Johnston,Dirk Kuypers,Yannick Le Meur,Pierre Marquet,Michael Oellerich,Eric Thervet,Burkhand Toenshoff,Nas Undre,Lutz T. Weber,Ian S. Westley,Michel Mourad +15 more
TL;DR: The importance of obtaining multicenter prospective trials to assess the efficacy of alternative strategies to TAC trough concentrations is emphasized, and single time points, limited sampling strategies, and area under concentration-time curve have all been considered to determine the most appropriate sampling procedure that correlates with efficacy.
Journal ArticleDOI
Tutorial review on validation of liquid chromatography-mass spectrometry methods: part II.
Anneli Kruve,Riin Rebane,Karin Kipper,Maarja-Liisa Oldekop,Hanno Evard,Koit Herodes,Pekka Ravio,Ivo Leito +7 more
TL;DR: This is the part II of a tutorial review intending to give an overview of the state of the art of method validation in liquid chromatography mass spectrometry and discuss specific issues that arise with MS (and MS-MS) detection in LC (as opposed to the "conventional" detectors).
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Current Role of Liquid Chromatography-Mass Spectrometry in Clinical and Forensic Toxicology
TL;DR: LC-MS will probably become a gold standard for detection of very low concentrations particularly in alternative matrices and for quantification in clinical and forensic toxicology, however, some drawbacks still need to be addressed and finally overcome.
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A decade of HPLC-MS/MS in the routine clinical laboratory--goals for further developments.
Michael Vogeser,Christoph Seger +1 more
TL;DR: HPLC-MS/MS has the potential to be further developed to a commonly applied high-throughput technique in clinical chemistry, complementary to present standard techniques as photometry and ligand binding methods.
References
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Journal ArticleDOI
Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.
TL;DR: Practical, experimental approaches for studying, identifying, and eliminating the effect of matrix on the results of quantitative analyses by HPLC-MS/MS are described and it is demonstrated that, for the investigational drug under study, the matrix effect was clearly observed when ISP interface was utilized but it was absent when the HN interface was employed.
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Harmonized guidelines for single-laboratory validation of methods of analysis (IUPAC Technical Report)
TL;DR: In this article, the Working Group that produced these protocols/guidelines has now been mandated by IUPAC to prepare guidelines on the single-laboratory validation of methods of analysis, providing minimum recommendations on procedures that should be employed to ensure adequate validation of analytical methods.
Book
Handbook of Chemometrics and Qualimetrics: Part A
Desire Massart,Bernard G. M. Vandeginste,Lutgarde M. C. Buydens,Paul J. Lewi,Johanna Smeyers-Verbeke,S. De Jong +5 more
Journal ArticleDOI
Bioanalytical method validation--a revisit with a decade of progress.
Vinod P. Shah,Kamal K. Midha,John W. A. Findlay,Howard Hill,James D. Hulse,Iain J. McGilveray,Gordon McKay,Krys J. Miller,Rabindra Patnaik,Mark L. Powell,Alfred P. Tonelli,C. T. Viswanathan,Avraham Yacobi +12 more
TL;DR: The purpose of this report is to represent the progress in analytical methodologies over the last decade and assessment of the major agreements and issues discussed with regard to small molecules at both the conference and the workshop.
Journal ArticleDOI
Ion Suppression in Mass Spectrometry
TL;DR: Options for minimizing or correcting ion suppression are presented, which include enhanced specimen cleanup, chromatographic changes, reagent modifications, and effective internal standardization.