F
Frank Rösch
Researcher at University of Mainz
Publications - 292
Citations - 8666
Frank Rösch is an academic researcher from University of Mainz. The author has contributed to research in topics: In vivo & DOTA. The author has an hindex of 46, co-authored 282 publications receiving 7718 citations. Previous affiliations of Frank Rösch include Dresden University of Technology & Joint Institute for Nuclear Research.
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Journal ArticleDOI
Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving.
Andreas Heinz,Thomas Siessmeier,Jana Wrase,Derik Hermann,Sabine Klein,Sabine M. Grüsser-Sinopoli,Herta Flor,Dieter F. Braus,Hans Georg Buchholz,Gerhard Gründer,Mathias Schreckenberger,Michael N. Smolka,Frank Rösch,Karl Mann,Peter Bartenstein +14 more
TL;DR: In alcoholics, dopaminergic dysfunction in the ventral striatum may attribute incentive salience to alcohol-associated stimuli, so that alcohol cues elicit craving and excessive activation of neural networks associated with attention and behavior control.
Journal ArticleDOI
Processing of Generator-Produced 68Ga for Medical Application
Konstantin Zhernosekov,Dimitry Filosofov,Richard P. Baum,Peter Aschoff,Heiner Bihl,Anatoli A. Razbash,Markus Jahn,Mark Jennewein,Frank Rösch +8 more
TL;DR: In this article, an efficient post-eluate processing of generator-derived 68Ge/68Ga eluates, including the labeling and purification of biomolecules, is presented.
Journal ArticleDOI
Correlation of alcohol craving with striatal dopamine synthesis capacity and D2/3 receptor availability: a combined [18F]DOPA and [18F]DMFP PET study in detoxified alcoholic patients.
Andreas Heinz,Thomas Siessmeier,Jana Wrase,Hans Georg Buchholz,Gerhard Gründer,Yoshitaka Kumakura,Paul Cumming,Mathias Schreckenberger,Michael N. Smolka,Frank Rösch,Karl Mann,Peter Bartenstein +11 more
TL;DR: Simultaneous assay by PET of pre- and postsynaptic markers of dopamine neurotransmission indicated that a striatal dopamine deficit correlated with alcohol craving, which was associated with a high relapse risk.
Journal ArticleDOI
Association of Low Striatal Dopamine D2 Receptor Availability With Nicotine Dependence Similar to That Seen With Other Drugs of Abuse
Christoph Fehr,Igor Yakushev,Nina Hohmann,Hans-Georg Buchholz,Christian Landvogt,Hanna Deckers,Alexandra Eberhardt,Marie Kläger,Michael N. Smolka,Armin Scheurich,Thomas F. Dielentheis,Lutz G. Schmidt,Frank Rösch,Peter Bartenstein,Gerhard Gründer,Mathias Schreckenberger +15 more
TL;DR: In contrast to previous findings on abstinent alcohol-dependent patients, nicotine craving seems to be maintained by a region-specific shift in D(2)/D(3) receptor availabilities, with higher availability within the ventral striatum but lower availabilityWithin the anterior cingulate and inferior temporal cortex.
Journal ArticleDOI
High opiate receptor binding potential in the human lateral pain system.
Ulf Baumgärtner,Hans-Georg Buchholz,Alexander Bellosevich,Walter Magerl,Thomas Siessmeier,Roman Rolke,S. Höhnemann,Markus Piel,Frank Rösch,Hans-Jürgen Wester,Gjermund Henriksen,Peter Stoeter,Peter Bartenstein,Rolf-Detlef Treede,Mathias Schreckenberger +14 more
TL;DR: The findings suggest that the cortical anti-nociceptive effects of opiates are not only mediated by ACC and MCC, but also by the operculo-insular cortex, if it can be assumed that opioid binding mediates anti- nociception in those structures.