F
Frank T. Kolligs
Researcher at Ludwig Maximilian University of Munich
Publications - 103
Citations - 3747
Frank T. Kolligs is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Colorectal cancer & Hepatocellular carcinoma. The author has an hindex of 29, co-authored 98 publications receiving 3383 citations. Previous affiliations of Frank T. Kolligs include German Cancer Research Center & Klinikum der Universität München.
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Journal ArticleDOI
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
Armando Santoro,Lorenza Rimassa,Ivan Borbath,Bruno Daniele,Stefania Salvagni,Jean-Luc Van Laethem,Hans Van Vlierberghe,Jörg Trojan,Frank T. Kolligs,Alan Weiss,Steven A. Miles,Antonio Gasbarrini,Monica Lencioni,Luca Cicalese,Morris Sherman,Cesare Gridelli,Peter Buggisch,Guido Gerken,Roland M. Schmid,Corrado Boni,Nicola Personeni,Ziad Hassoun,Giovanni Abbadessa,Brian Schwartz,Reinhard von Roemeling,Maria Lamar,Yinpu Chen,Camillo Porta +27 more
TL;DR: Tivantinib could provide an option for second-line treatment of patients with advanced hepatocellular carcinoma and well-compensated liver cirrhosis, particularly for patients with MET-high tumours.
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Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
TL;DR: The main function of APC is thought to be the regulation of free beta-catenin in concert with the glycogen synthase kinase 3beta (GSK-3beta) and Axin proteins.
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Comprehensive analysis of β-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/β-catenin signaling
Andreas Herbst,Vindi Jurinovic,Stefan Krebs,Susanne E. Thieme,Helmut Blum,Burkhard Göke,Frank T. Kolligs +6 more
TL;DR: DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study Wnt/β- catenin signaling and associated colorectal carcinogenesis and the confirmed and the newly identified potential β-catenin target genes are useful starting points for further studies.
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Transarterial Hepatic Yttrium-90 Radioembolization in Patients with Unresectable Intrahepatic Cholangiocarcinoma: Factors Associated with Prolonged Survival
Ralf-T. Hoffmann,Philipp M. Paprottka,Agnes Schön,Fabian Bamberg,Alexander Haug,Eva-Maria Dürr,Barbara Rauch,Christoph Trumm,Tobias F. Jakobs,Thomas Helmberger,Maximilian F. Reiser,Frank T. Kolligs +11 more
TL;DR: Radioembolization is an effective and safe option for patients with unresectable ICC and predictors for prolonged survival are performance status, tumor burden, and RECIST response.
Journal ArticleDOI
Methylation of serum DNA is an independent prognostic marker in colorectal cancer.
Maike Wallner,Andreas Herbst,Andrea Behrens,Alexander Crispin,Petra Stieber,Burkhard Göke,Rolf Lamerz,Frank T. Kolligs +7 more
TL;DR: In this article, the methylation status of specific genes in the serum of patients with colorectal cancer has the potential to become a pretherapeutic predictor of outcome.