Vindi Jurinovic

TL;DR: Maximal interleukin-6 levels before intubation showed the strongest association with the need of mechanical ventilation followed by maximal CRP, suggesting the possibility of using IL-6 or CRP levels to guide escalation of treatment in patients with COVID-19 related hyperinflammatory syndrome.

TL;DR: This work aimed to improve risk stratification of patients receiving first-line immunochemotherapy by integrating gene mutations into a prognostic model by establishing a clinicogenetic risk model that included the Follicular Lymphoma International Prognostic Index (FLIPI) and Eastern Cooperative Oncology Group (ECOG) performance status.

TL;DR: DLD1 and SW480 colon carcinoma cell lines are suitable model systems to study Wnt/β- catenin signaling and associated colorectal carcinogenesis and the confirmed and the newly identified potential β-catenin target genes are useful starting points for further studies.

TL;DR: The m7-FLIPI prospectively identifies the smallest subgroup of patients at highest risk of early failure of first-line immunochemotherapy and death, including patients not fulfilling the POD24 criteria, and should be evaluated in prospective trials of precision medicine approaches in FL.

TL;DR: A common prognostic gene signature composed of 24 genes was identified as an independent predictor of survival of patients with acute myeloid leukemia and the integrated risk classification incorporating this gene signature provides a better framework for risk stratification and outcome prediction than the ELN classification.