F
Frank W. DelRio
Researcher at National Institute of Standards and Technology
Publications - 122
Citations - 3536
Frank W. DelRio is an academic researcher from National Institute of Standards and Technology. The author has contributed to research in topics: Surface roughness & Nanoparticle. The author has an hindex of 27, co-authored 106 publications receiving 2857 citations. Previous affiliations of Frank W. DelRio include University of California, Berkeley & University of Colorado Boulder.
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Journal ArticleDOI
The role of van der Waals forces in adhesion of micromachined surfaces
Frank W. DelRio,Frank W. DelRio,Maarten P. de Boer,James Arthur Knapp,E. David Reedy,Peggy J. Clews,Martin L. Dunn +6 more
TL;DR: It is demonstrated that the adhesion of micromachined surfaces is in a regime not considered by standard rough surface adhesion models and suggested that topographic correlations between the upper and lower surfaces must be considered to understand adhesion completely.
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Adsorption and conformation of serum albumin protein on gold nanoparticles investigated using dimensional measurements and in situ spectroscopic methods.
De-Hao Tsai,Frank W. DelRio,Athena M. Keene,Katherine M. Tyner,Robert I. MacCuspie,Tae Joon Cho,Michael R. Zachariah,Michael R. Zachariah,Vincent A. Hackley +8 more
TL;DR: The adsorption and conformation of bovine serum albumin (BSA) on gold nanoparticles (AuNPs) were interrogated both qualitatively and quantitatively via complementary physicochemical characterization methods.
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Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments
Adrianne M. Rosales,Adrianne M. Rosales,Sebastián L. Vega,Frank W. DelRio,Jason A. Burdick,Kristi S. Anseth,Kristi S. Anseth +6 more
TL;DR: Haluronic acid-based substrates capable of sequential photodegradation and photoinitiated crosslinking reactions to soften and then stiffen the hydrogels over a physiologically relevant range of moduli are developed, rendering this platform amenable to studies of dynamic mechanics on cell behavior across many cell types and contexts.
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Spatially patterned matrix elasticity directs stem cell fate.
Chun Yang,Frank W. DelRio,Hao Ma,Anouk R. Killaars,Lena P. Basta,Kyle A. Kyburz,Kristi S. Anseth +6 more
TL;DR: It is inferred that irregular, disorganized variations in matrix mechanics appear to disrupt actin organization, and lead to different cell fates; this was verified by observations of lower alkaline phosphatase (ALP) activity and higher expression of CD105, a stem cell marker, in hMSCs in random versus regular patterns of mechanical properties.
Journal ArticleDOI
Tissue geometry drives deterministic organoid patterning
Nikolce Gjorevski,Mikhail Nikolaev,Tobin E. Brown,Olga Mitrofanova,Nathalie Brandenberg,Frank W. DelRio,F. Max Yavitt,Prisca Liberali,Kristi S. Anseth,Matthias P. Lutolf +9 more
TL;DR: This work has attempted to control the patterning and morphogenesis of intestinal organoids via the physical properties and, in particular, the initial geometry of the tissue itself, and suggests that in vivo–like tissue geometries can drive stereotypical epithelial patterning by establishing reproducible local differences in cell packing and morphology.