F
Fred Jacobs
Publications - 3
Citations - 184
Fred Jacobs is an academic researcher. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 3, co-authored 3 publications receiving 179 citations.
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Journal ArticleDOI
Mucin 1-specific immunotherapy in a mouse model of spontaneous breast cancer.
Pinku Mukherjee,Cathy S. Madsen,Amelia R. Ginardi,Teresa L. Tinder,Fred Jacobs,Joanne Parker,Babita Agrawal,B. Michael Longenecker,Sandra J. Gendler +8 more
TL;DR: Using an injectable breast cancer model, the authors show that targeting a single tumor antigen may not be an effective antitumor treatment, but that immunization with dendritic cells fed with whole tumor lysate is effective in breaking tolerance and protecting mice from subsequent tumor challenge.
Journal ArticleDOI
MUC1-specific CTLs are non-functional within a pancreatic tumor microenvironment.
Pinku Mukherjee,Amelia R. Ginardi,Cathy S. Madsen,Teresa L. Tinder,Fred Jacobs,Joanne Parker,Babita Agrawal,B. Michael Longenecker,Sandra J. Gendler +8 more
TL;DR: It is demonstrated that the CTL tolerance could be reversed at least in vitro with the use of anti-CD40 co-stimulation, which indicates theuse of several immune evasion mechanisms by tumor cells to evade CTL killing.
Journal ArticleDOI
Association of MUC-1 and PSGL-1 with Low-Density Microdomain in T-Lymphocytes: A Preliminary Note
Kazuko Handa,Kazuko Handa,Fred Jacobs,B. Michael Longenecker,Sen-itiroh Hakomori,Sen-itiroh Hakomori +5 more
TL;DR: Findings indicate the presence of another glycosyl cluster ("glycocluster"), in addition to the previously well-established GSL cluster organized with signal transducer molecules in GEM fraction, and its possible functional role in T-cells.