F
Frederico G.S. Toledo
Researcher at University of Pittsburgh
Publications - 77
Citations - 5868
Frederico G.S. Toledo is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Insulin resistance & Diabetes mellitus. The author has an hindex of 35, co-authored 63 publications receiving 5105 citations. Previous affiliations of Frederico G.S. Toledo include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.
Stephanie J. Mihalik,Bret H. Goodpaster,David E. Kelley,Donald H. Chace,Jerry Vockley,Frederico G.S. Toledo,James P. DeLany +6 more
TL;DR: This study focused on characterizing AcylCN profiles in human plasma from individuals with obesity and T2DM during fasting and insulin‐stimulated conditions, suggesting that more fatty acids can enter mitochondria.
Journal ArticleDOI
Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?
Francesca Amati,John J. Dubé,Elvis Alvarez-Carnero,Martin M. Edreira,Peter J. Chomentowski,Paul M. Coen,Galen E. Switzer,Galen E. Switzer,Perry E. Bickel,Maja Stefanovic-Racic,Frederico G.S. Toledo,Bret H. Goodpaster +11 more
TL;DR: Total myocellular D AGs were markedly higher in highly trained athletes, corresponding with higher insulin sensitivity, and suggest a more complex role for DAGs in insulin action.
Journal ArticleDOI
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited.
John J. Dubé,Francesca Amati,Maja Stefanovic-Racic,Frederico G.S. Toledo,Sarah E. Sauers,Bret H. Goodpaster +5 more
TL;DR: It is demonstrated that chronic exercise in overweight to obese older adults improves insulin sensitivity in conjunction with favorable alterations in lipid partitioning and an enhanced oxidative capacity within muscle can be reversed with only moderate increases in physical activity.
Journal ArticleDOI
Effects of Physical Activity and Weight Loss on Skeletal Muscle Mitochondria and Relationship With Glucose Control in Type 2 Diabetes
Frederico G.S. Toledo,Elizabeta V. Menshikova,Vladimir B. Ritov,Koichiro Azuma,Zofia Radikova,James P. DeLany,David E. Kelley +6 more
TL;DR: Intensive short-term lifestyle modifications can restore mitochondrial content and functional capacity in skeletal muscle in type 2 diabetic patients and may be a key component mediating salutary effects of lifestyle interventions on hyperglycemia and insulin resistance.
Journal ArticleDOI
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
Vladimir B. Ritov,Elizabeth V. Menshikova,Koichiro Azuma,Richard J Wood,Frederico G.S. Toledo,Bret H. Goodpaster,Neil B. Ruderman,David E. Kelley +7 more
TL;DR: The presented study concludes that the total activity of NADH oxidase in biopsy for lean group is significantly higher than corresponding activity for obese or T2DM cohort.