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Stephanie J. Mihalik
Researcher at University of Pittsburgh
Publications - 11
Citations - 1119
Stephanie J. Mihalik is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Fatty acid & Internal medicine. The author has an hindex of 8, co-authored 9 publications receiving 920 citations.
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Journal ArticleDOI
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.
Stephanie J. Mihalik,Bret H. Goodpaster,David E. Kelley,Donald H. Chace,Jerry Vockley,Frederico G.S. Toledo,James P. DeLany +6 more
TL;DR: This study focused on characterizing AcylCN profiles in human plasma from individuals with obesity and T2DM during fasting and insulin‐stimulated conditions, suggesting that more fatty acids can enter mitochondria.
Journal ArticleDOI
Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth With Obesity and Type 2 Diabetes: Evidence for enhanced mitochondrial oxidation
Stephanie J. Mihalik,Sara F. Michaliszyn,Javier de las Heras,Fida Bacha,SoJung Lee,Donald H. Chace,Victor R. DeJesus,Jerry Vockley,Silva A. Arslanian +8 more
TL;DR: In this article, the authors compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW), obese (OB), and type 2 diabetic (n = 17) adolescents.
Journal ArticleDOI
Evidence for Physical Association of Mitochondrial Fatty Acid Oxidation and Oxidative Phosphorylation Complexes
TL;DR: Evidence is provided of a multifunctional FAO complex within mitochondria that is physically associated with OXPHOS supercomplexes and promotes metabolic channeling.
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Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.
Aris Polyzos,Do Yup Lee,Rupsa Datta,Meghan Hauser,Helen Budworth,Amy Holt,Stephanie J. Mihalik,Pike Goldschmidt,Ken A. Frankel,Kelly S. Trego,Michael J. Bennett,Jerry Vockley,Ke Xu,Ke Xu,Enrico Gratton,Cynthia T. McMurray +15 more
TL;DR: It is shown that region-specific neuronal vulnerability is a substrate-driven response in astrocytes, and metabolically reprogramming their mitochondria to use endogenous, non-glycolytic metabolites as an alternative fuel in each brain region.
Journal ArticleDOI
Metabolomic Profiling of Amino Acids and β-Cell Function Relative to Insulin Sensitivity in Youth
Sara Fleet Michaliszyn,Lindsey A. Sjaarda,Stephanie J. Mihalik,SoJung Lee,Fida Bacha,Donald H. Chace,Víctor R. De Jesús,Jerry Vockley,Silva A. Arslanian +8 more
TL;DR: In youth, increased plasma AA concentrations are not associated with a heightened metabolic risk profile for T2DM; rather, they are positively associated with β-cell function relative to insulin sensitivity; these contrasting observations between adults and youth may be a reflection of developmental differences along the lifespan dependent on the combined impact of the aging process together with the impact of progressive obesity.