F
Fredrik Klevebro
Researcher at Karolinska University Hospital
Publications - 78
Citations - 1046
Fredrik Klevebro is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Esophagectomy & Medicine. The author has an hindex of 11, co-authored 48 publications receiving 702 citations. Previous affiliations of Fredrik Klevebro include Karolinska Institutet & Virginia Mason Medical Center.
Papers
More filters
Journal ArticleDOI
A randomized clinical trial of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the oesophagus or gastro-oesophageal junction
Fredrik Klevebro,G. Alexandersson von Döbeln,N. Wang,Gjermund Johnsen,Anne-Birgitte Jacobsen,Signe Friesland,Ingunn Hatlevoll,Nils Glenjen,Pehr Lind,Jon A. Tsai,Lars Lundell,Magnus Nilsson +11 more
TL;DR: The addition of radiotherapy to neoadjuvant chemotherapy results in higher histological complete response rate, higher R0 resection rate, and a lower frequency of lymph-node metastases, without significantly affecting survival.
Journal ArticleDOI
Meta-analysis of postoperative morbidity and perioperative mortality in patients receiving neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal and gastro-oesophageal junctional cancers.
Koshi Kumagai,Ioannis Rouvelas,Jon A. Tsai,Daniela Mariosa,Fredrik Klevebro,Mats Lindblad,Weimin Ye,Lars Lundell,Magnus Nilsson +8 more
TL;DR: The long‐term survival benefits of neoadjuvant chemotherapy and chemoradiotherapy for oesophageal carcinoma are well established, however, both are burdened by toxicity that could contribute to perioperative morbidity and mortality.
Journal ArticleDOI
Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus or gastroesophageal junction: long-term results of a randomized clinical trial.
G. A. Von Döbeln,Fredrik Klevebro,Anne-Birgitte Jacobsen,Hans-Olaf Johannessen,Niels Hilmer Nielsen,Gjermund Johnsen,Ingunn Hatlevoll,Nils Glenjen,Signe Friesland,Lars Lundell,Jingru Yu,Magnus Nilsson +11 more
TL;DR: The results do not support unselected addition of radiotherapy to neoadjuvant chemotherapy as a standard of care in patients with resectable esophageal cancer.
Journal ArticleDOI
Morbidity and mortality after surgery for cancer of the oesophagus and gastro-oesophageal junction: A randomized clinical trial of neoadjuvant chemotherapy vs. neoadjuvant chemoradiation.
Fredrik Klevebro,Gjermund Johnsen,Egil Johnson,Asgaut Viste,T. Myrnas,Eva Szabo,Anne-Birgitte Jacobsen,Signe Friesland,Jon A. Tsai,Saga Persson,Mats Lindblad,Lars Lundell,Magnus Nilsson +12 more
TL;DR: There was no significant difference in the incidence of complications between patients randomized to nCT and n CRT, however, complications were significantly more severe after nCRT.
Journal ArticleDOI
Cardiorespiratory Comorbidity and Postoperative Complications following Esophagectomy: a European Multicenter Cohort Study
Fredrik Klevebro,Jessie A Elliott,Annelijn E. Slaman,B. D. Vermeulen,S. Kamiya,S. Kamiya,Camiel Rosman,Suzanne S. Gisbertz,Piers R. Boshier,John V. Reynolds,Ioannis Rouvelas,Ioannis Rouvelas,George B. Hanna,M. I. van Berge Henegouwen,Sheraz R. Markar +14 more
TL;DR: It is suggested that cardiorespiratory comorbidity and impaired pulmonary function are associated with increased risk of postoperative complications after esophagectomy performed in high-volume European centers.