F
Fritz G. Parak
Researcher at Technische Universität München
Publications - 155
Citations - 6154
Fritz G. Parak is an academic researcher from Technische Universität München. The author has contributed to research in topics: Myoglobin & Scattering. The author has an hindex of 37, co-authored 155 publications receiving 5998 citations. Previous affiliations of Fritz G. Parak include Max Planck Society & Ludwig Maximilian University of Munich.
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Journal Article
Locoregional Cancer Treatment with Magnetic Drug Targeting
Christoph Alexiou,Wolfgang Arnold,R. Klein,Fritz G. Parak,P. Hulin,Christian Bergemann,Wolfgang Erhardt,Stefan Wagenpfeil,Andreas S. Lübbe +8 more
TL;DR: This "magnetic drug targeting" offers a unique opportunity to treat malignant tumors locoregionally without systemic toxicity and may be possible to use these magnetic particles as a "carrier system" for a variety of anticancer agents, e.g., radionuclides, cancer-specific antibodies, and genes.
Journal ArticleDOI
Ligand binding and conformational motions in myoglobin
TL;DR: It is shown that below 180 K photodissociated ligands migrate to specific sites within an internal cavity—the distal haem pocket— of an essentially immobilized, frozen protein, from where they subsequently rebind by thermally activated barrier crossing.
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Targeting cancer cells: magnetic nanoparticles as drug carriers
Christoph Alexiou,R. Schmid,Roland Jurgons,Marcus Kremer,Gerhard Wanner,Christian Bergemann,Ernst Huenges,Thomas Nawroth,Wolfgang Arnold,Fritz G. Parak +9 more
TL;DR: It is shown that a strong magnetic field gradient at the tumour location accumulates the nanoparticles and electron microscope investigations show that the ferrofluids can be enriched in tumour tissue and tumour cells.
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Protein dynamics. Mössbauer spectroscopy on deoxymyoglobin crystals.
TL;DR: Mossbauer absorption experiments on 57 Fe of deoxygenated myoglobin crystals and on K 4 57 Fe(CN) 6 dissolved in the water of metmyoglobin crystals were performed over a large temperature range, finding that the surface water mediates a possible trigger mechanism that switches on protein dynamics within a narrow temperature interval.
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Magnetic drug targeting--biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment.
Christoph Alexiou,Roland Jurgons,R. Schmid,Christian Bergemann,Julia Henke,Wolf Erhardt,Ernst Huenges,Fritz G. Parak +7 more
TL;DR: The higher concentration of mitoxantrone could explain the therapeutic efficacy of Magnetic Drug Targeting in treatment of VX2 squamous cell carcinoma in rabbits in previous studies with the advantage of no adverse clinical side effects.