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Fumio Kokubu
Researcher at Showa University
Publications - 73
Citations - 2915
Fumio Kokubu is an academic researcher from Showa University. The author has contributed to research in topics: Chemokine & Asthma. The author has an hindex of 27, co-authored 73 publications receiving 2762 citations.
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Journal ArticleDOI
IL-17 cytokine family
Mio Kawaguchi,Mio Kawaguchi,Mitsuru Adachi,Naruhito Oda,Naruhito Oda,Fumio Kokubu,Shau Ku Huang +6 more
TL;DR: The potent inflammatory activity and its association with various human disease states suggest this new cytokine family as an important contributor to the pathophysiology of human disease conditions, in particular the pulmonary diseases.
Journal ArticleDOI
IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity.
Mio Kawaguchi,Daisuke Takahashi,Nobuyuki Hizawa,Shintaro Suzuki,Satoshi Matsukura,Fumio Kokubu,Yukiko Maeda,Yoshinobu Fukui,Satoshi Konno,Shau Ku Huang,Masaharu Nishimura,Mitsuru Adachi +11 more
TL;DR: Genetic analyses of association of asthma with the common variants of IL17F indicate that the IL-17F H161R variant influences the risk of asthma and is a natural IL- 17F antagonist, suggesting a potential role for IL-16F in the etiology of asthma.
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Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A
TL;DR: Festival virus infection may stimulate production of IL-6, IL-8, and RANTES from human bronchial epithelial cells and that these cytokines may contribute to the pathogenesis of airway inflammatory diseases caused by influenza virus infection.
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Modulation of bronchial epithelial cells by IL-17
Mio Kawaguchi,Mio Kawaguchi,Fumio Kokubu,Hideki Kuga,Satoshi Matsukura,Hiroshi Hoshino,Koushi Ieki,Imai T,Mitsuru Adachi,Shau Ku Huang +9 more
TL;DR: It is suggested that IL-17, alone or in combination with other cytokines, modulates airway inflammation via-in part-the expression of epithelial IL-6, IL-8, and ICAM-1.
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Clinical and microbiological differences between Mycobacterium abscessus and Mycobacterium massiliense lung diseases
Toshiyuki Harada,Yasushi Akiyama,Atsuyuki Kurashima,Hideaki Nagai,Kazunari Tsuyuguchi,Takashi Fujii,Syuichi Yano,Eriko Shigeto,Toshihiko Kuraoka,Akira Kajiki,Yoshihiro Kobashi,Fumio Kokubu,Atsuo Sato,Shiomi Yoshida,Tomotada Iwamoto,Hajime Saito +15 more
TL;DR: Clinical and radiological findings were indistinguishable between the M. abscessus and M. massiliense groups, and both groups showed a high level of resistance to all antimicrobials, except for clarithromycin, kanamycin, and amikacin.