F
Fumitaka Hayase
Researcher at Meiji University
Publications - 57
Citations - 1193
Fumitaka Hayase is an academic researcher from Meiji University. The author has contributed to research in topics: Maillard reaction & Glycation. The author has an hindex of 20, co-authored 57 publications receiving 1092 citations. Previous affiliations of Fumitaka Hayase include Tokyo Medical and Dental University.
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Journal ArticleDOI
Peroxynitrite Induces Formation of Nε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite
Ryoji Nagai,Yuka Unno,Miki Cristina Hayashi,Shuichi Masuda,Fumitaka Hayase,Naohide Kinae,Seikoh Horiuchi +6 more
TL;DR: The results provide the first evidence that ONOO(-) can induce protein modification by oxidative cleavage of the Amadori product and also by generation of reactive alpha-oxoaldehydes from glucose.
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Effects of Oxygen and Transition Metals on the Advanced Maillard Reaction of Proteins with Glucose
TL;DR: The generation of fluorescence and 3-deoxyglucosone (3DG), browning, polymerization, and impairment of the amino acid residues of lysozyme incubated with glucose were investigated under aerobic and non-aerobic conditions with or without DETAPAC as a chelating reagent.
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Amyloid β2-microglobulin is modified with imidazolone, a novel advanced glycation end product, in dialysis-related amyloidosis
Toshimitsu Niwa,Tomoyuki Katsuzaki,Tomoyuki Katsuzaki,Shigeru Miyazaki,Shigeru Miyazaki,Tomoko Momoi,Tomoko Momoi,Takashi Akiba,Takashi Akiba,Takashi Miyazaki,Takashi Miyazaki,Kazuya Nokura,Kazuya Nokura,Fumitaka Hayase,Fumitaka Hayase,Noriyuki Tatemichi,Noriyuki Tatemichi,Takei Yoshifumi,Takei Yoshifumi +18 more
TL;DR: Amyloid tissue β2m is modified with imidazolone in patients with DRA, and 3-DG accumulating in uremic serum may be involved in the modification ofβ2m with imdazol one.
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Conversion of Amadori Products of the Maillard Reaction to Ne-(carboxymethyl)lysine by Short-Term Heating: Possible Detection of Artifacts by Immunohistochemistry
Cristina Miki Hayashi,Ryoji Nagai,Kiminori Miyazaki,Fumitaka Hayase,Tomohiro Araki,Tomomichi Ono,Seikoh Horiuchi +6 more
TL;DR: Reactive intermediates such as glucosone, 3-deoxyglucos one, methylglyoxal, and glyoxal were formed upon heat treatment of glycated HSA at 100° C, indicating that these aldehydes generated from Amadori products by oxidative cleavage can contribute to further CML formation.