Fuquan Zhang

TL;DR: It is predicted that half to two-thirds of the approximately 150 genes encoded by ASFV are not essential for replication in cells but have an important role for virus survival and transmission in its hosts.

TL;DR: It is hypothesized that ASFV has other mechanisms to prevent the eIF2α phosphorylation and the subsequent protein synthesis inhibition, and it is demonstrated that DP71L causes dephosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 α) in resting cells and during chemical-induced endoplasmic reticulum stress and acts to enhance expression of cotransfected reporter genes.

TL;DR: It is shown that the virus persists for up to 400 days in buffaloes and that there is competition between viruses during mixed infections, which may provide a mechanism for the dominance of particular viruses in an ecosystem.

TL;DR: A porcine microarray containing 2,880 cDNAs was used to investigate the response of macrophages to infection by a virulent African swine fever virus (ASFV) isolate, Malawi LIL20/1, and revealed differences between these two ASFV isolates in the amounts of these cytokines secreted from infected cells.

TL;DR: It is demonstrated thatCVB3 capsid proteins expressed in insect cells have the intrinsic capacity to assemble into non-infectious VLP, which afforded protection from CVB3 infection to mice when used as a vaccine.