F
Fuyuko Takata
Researcher at Fukuoka University
Publications - 64
Citations - 2222
Fuyuko Takata is an academic researcher from Fukuoka University. The author has contributed to research in topics: Blood–brain barrier & Pericyte. The author has an hindex of 22, co-authored 47 publications receiving 1698 citations.
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Journal ArticleDOI
Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production
Shinya Dohgu,Fuyuko Takata,Atsushi Yamauchi,Shinsuke Nakagawa,Takashi Egawa,Mikihiko Naito,Takashi Tsuruo,Yasufumi Sawada,Masami Niwa,Yasufumi Kataoka +9 more
TL;DR: It is suggested that brain pericytes contribute to the up-regulation of BBB functions through continuous TGF-beta production.
Journal ArticleDOI
Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice
Tsuyoshi Nishioku,Shinya Dohgu,Fuyuko Takata,Tomoaki Eto,Naoko Ishikawa,Kota Kodama,Shinsuke Nakagawa,Atsushi Yamauchi,Yasufumi Kataoka +8 more
TL;DR: The findings suggest that pericyte detachment and microglial activation may be involved in the mediation of BBB disruption due to inflammatory responses in the damaged brain.
Journal ArticleDOI
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro
Fuyuko Takata,Shinya Dohgu,Junichi Matsumoto,Hiroyuki Takahashi,Takashi Machida,Tomoya Wakigawa,Eriko Harada,Haruki Miyaji,Mitsuhisa Koga,Tsuyoshi Nishioku,Atsushi Yamauchi,Yasufumi Kataoka +11 more
TL;DR: It is suggested that pericytes are most sensitive to TNF-α in terms of MMP-9 release, and are the major source of M MP-9 at the BBB.
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Lipopolysaccharide-Activated Microglia Induce Dysfunction of the Blood–Brain Barrier in Rat Microvascular Endothelial Cells Co-Cultured with Microglia
Noriko Sumi,Tsuyoshi Nishioku,Fuyuko Takata,Junichi Matsumoto,Takuya Watanabe,Hideki Shuto,Atsushi Yamauchi,Shinya Dohgu,Yasufumi Kataoka +8 more
TL;DR: The present findings suggest that LPS activates microglia to induce dysfunction of the BBB by producing reactive oxygen species through NADPH oxidase.
Journal ArticleDOI
Tumor Necrosis Factor-α Mediates the Blood–Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells
Tsuyoshi Nishioku,Junichi Matsumoto,Shinya Dohgu,Noriko Sumi,Kenji Miyao,Fuyuko Takata,Hideki Shuto,Atsushi Yamauchi,Yasufumi Kataoka +8 more
TL;DR: Findings suggested that TNF-α released from activated microglia is attributable to BBB dysfunction, and this hyper-permeability was blocked by a neutralizing antibody against TNF -α.