G
G.B. De Sarro
Researcher at Magna Græcia University
Publications - 85
Citations - 2652
G.B. De Sarro is an academic researcher from Magna Græcia University. The author has contributed to research in topics: Anticonvulsant & Epilepsy. The author has an hindex of 27, co-authored 85 publications receiving 2568 citations. Previous affiliations of G.B. De Sarro include Mediterranea University of Reggio Calabria & Health Science University.
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Evidence that locus coeruleus is the site where clonidine and drugs acting at α1‐ and α2‐adrenoceptors affect sleep and arousal mechanisms
TL;DR: The behavioural and ECoG spectrum power effects of clonidine given into the third cerebral ventricle or into the locus coeruleus were prevented by antagonists of α2‐adrenoceptors but not by α1‐ adrenoceptor antagonists.
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Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Silvana Grasso,G.B. De Sarro,A. De Sarro,Nicola Micale,Maria Zappalà,G Puja,Baraldi M,C. De Micheli +7 more
TL;DR: The synthesis of a series of novel substituted 4-aryl-6,7-methylenedioxyphthalazin-1(2H)-ones, which shows a longer lasting anticonvulsant activity against audiogenic seizures and antagonizes in vivo seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) and kainate (KA).
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Anticonvulsant effects of some calcium entry blockers in DBA/2 mice
TL;DR: The present results strongly support the idea that some Ca2+ antagonists may be useful in human epilepsy.
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Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.
TL;DR: The EEG patterns suggest that the beta-lactam ring is a possible determinant of production of epileptogenic activity, with likely contributory factors in the substitutions at the 7-aminocephalosporanic or 6-aminopenicillanic acid that may increase or reduce the epilepsyptogenic properties of the Beta- lactam antibiotics.
Journal Article
Role of IL-6 in the Pleurisy and Lung Injury Caused by Carrageenan
S. Cuzzocrea,Lidia Sautebin,G.B. De Sarro,Giuseppina Costantino,Laura Rombolà,Emanuela Mazzon,Armando Ialenti,A. De Sarro,Gennaro Ciliberto,M. Di Rosa,Achille P. Caputi,Christoph Thiemermann +11 more
TL;DR: Results clearly demonstrate that IL-6KO mice are more resistant to the acute inflammation of the lung caused by carrageenan injection into the pleural space than the corresponding WT mice.