S
Silvana Grasso
Researcher at University of Messina
Publications - 119
Citations - 2388
Silvana Grasso is an academic researcher from University of Messina. The author has contributed to research in topics: Anticonvulsant & Proteasome. The author has an hindex of 27, co-authored 119 publications receiving 2171 citations. Previous affiliations of Silvana Grasso include University of Rome Tor Vergata & University of Illinois at Chicago.
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Journal ArticleDOI
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Silvana Grasso,G.B. De Sarro,A. De Sarro,Nicola Micale,Maria Zappalà,G Puja,Baraldi M,C. De Micheli +7 more
TL;DR: The synthesis of a series of novel substituted 4-aryl-6,7-methylenedioxyphthalazin-1(2H)-ones, which shows a longer lasting anticonvulsant activity against audiogenic seizures and antagonizes in vivo seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) and kainate (KA).
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Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.
TL;DR: The EEG patterns suggest that the beta-lactam ring is a possible determinant of production of epileptogenic activity, with likely contributory factors in the substitutions at the 7-aminocephalosporanic or 6-aminopenicillanic acid that may increase or reduce the epilepsyptogenic properties of the Beta- lactam antibiotics.
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1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Alba Chimirri,G. De Sarro,A. De Sarro,Rosaria Gitto,Silvana Grasso,S. Quartarone,M. Zappala,P. Giusti,Vincenzo Libri,A. Constanti,A. G. Chapman +10 more
TL;DR: The synthesis of new 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones and the evaluation of their anticonvulsant effects are described and the observed findings extend the structure-activity relationships previously suggested for this class of anticonVulsants.
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GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice
Giovambattista De Sarro,Alba Chimirri,Angela De Sarro,Rosaria Gitto,Silvana Grasso,P. Giusti,Astrid G. Chapman +6 more
TL;DR: The pharmacological actions of GYKI 52466, 2,3-BZ-2 and 2,5-dihydro-7,8-dimethoxy-1-phenyl-4H-2, 3-benzodiazepine derivatives as anticonvulsants, were significantly reduced by an i.c.p. administration of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
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Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma
Roberta Ettari,Maria Zappalà,Silvana Grasso,Caterina Musolino,Vanessa Innao,Alessandro Allegra +5 more
TL;DR: By selectively inhibiting the immunoproteasome, it may be possible to maintain the antimyeloma and antilymphoma efficacy while reducing these toxicities, thereby increasing the therapeutic index.