G
G P Hough
Researcher at University of California, Los Angeles
Publications - 9
Citations - 1175
G P Hough is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Monocyte & LDL receptor. The author has an hindex of 8, co-authored 9 publications receiving 1144 citations.
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Journal ArticleDOI
Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein
M Navab,S. Imes,Susan Hama,G P Hough,L. A. Ross,R W Bork,A J Valente,Judith A. Berliner,Davis C. Drinkwater,Hillel Laks +9 more
TL;DR: It is concluded that cocultures of human aortic cells can modify LDL even in the presence of serum, resulting in the induction of MCP-1, and that HDL and antioxidants prevent the LDL induced monocyte transmigration.
Journal ArticleDOI
Monocyte migration into the subendothelial space of a coculture of adult human aortic endothelial and smooth muscle cells.
TL;DR: The experiments indicate the need to study all three cell types (monocytes, EC, and SMC) together to understand the complex interactions that occur between these cells, and the endothelial monolayer was the principal permeability barrier.
Journal ArticleDOI
Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei × C57BL/6J)
Margarete Mehrabian,Lawrence W. Castellani,Ping-Zi Wen,Jack Wong,Tat Rithaporn,Susan Hama,G P Hough,David W. Johnson,John J. Albers,Giuliano A. Mottino,Joy S. Frank,Mohamad Navab,Alan M. Fogelman,Aldons J. Lusis +13 more
TL;DR: Low HDL lipid levels exhibited complex inheritance, as 12 quantitative trait loci with significant or suggestive likelihood of observed data scores were identified and novel genes are likely to be important in the control of HDL metabolism.
Journal ArticleDOI
Interaction of monocytes with cocultures of human aortic wall cells involves interleukins 1 and 6 with marked increases in connexin43 message.
M Navab,Feng Liao,G P Hough,L. A. Ross,B J Van Lenten,Tripathi B. Rajavashisth,Aldon J. Lusis,Hillel Laks,Davis C. Drinkwater,A M Fogelman +9 more
TL;DR: It is concluded that the interaction of HAEC, HASMC, and monocytes in coculture can result in marked increases in the levels of several biologically important molecules and that increased gap junction formation between the cells and interleukins 1 and 6 may be partially responsible for these changes.
Journal ArticleDOI
Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance.
M Navab,G P Hough,Judith A. Berliner,J A Frank,A M Fogelman,Margaret E. Haberland,Peter A. Edwards +6 more
TL;DR: It is concluded that preincubation of RAEC with beta-VLDL resulted in an increased permeability to LDL and albumin, and that beta- VLDL may promote increased transendothelial transport of macromolecules in cholesterol-fed rabbits.