P
Ping-Zi Wen
Researcher at University of California, Los Angeles
Publications - 10
Citations - 409
Ping-Zi Wen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Locus (genetics) & Quantitative trait locus. The author has an hindex of 9, co-authored 10 publications receiving 385 citations.
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Journal ArticleDOI
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
Luz D. Orozco,Brian J. Bennett,Charles R. Farber,Anatole Ghazalpour,Calvin Pan,Nam Che,Ping-Zi Wen,Hong Xiu Qi,Adonisa Mutukulu,Nathan O. Siemers,Isaac M. Neuhaus,Roumyana Yordanova,Peter S. Gargalovic,Matteo Pellegrini,Todd G. Kirchgessner,Aldons J. Lusis +15 more
TL;DR: A systems genetics strategy is used to examine the role of common genetic variation in macrophage responses to inflammatory stimuli and identified the gene 2310061C15Rik as a regulator of inflammatory responses in Macrophages.
Journal ArticleDOI
High-Resolution Mapping of Gene Expression Using Association in an Outbred Mouse Stock
Anatole Ghazalpour,Sudheer Doss,Hyun Min Kang,Charles R. Farber,Ping-Zi Wen,Alec J. Brozell,Ruth Castellanos,Eleazar Eskin,Desmond J. Smith,Thomas A. Drake,Aldons J. Lusis +10 more
TL;DR: This article applied whole-genome association analysis to hepatic gene expression traits in an outbred mouse population, the MF1 stock, and replicated expression QTL (eQTL) identified in previous studies of F2 intercross mice.
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Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei × C57BL/6J)
Margarete Mehrabian,Lawrence W. Castellani,Ping-Zi Wen,Jack Wong,Tat Rithaporn,Susan Hama,G P Hough,David W. Johnson,John J. Albers,Giuliano A. Mottino,Joy S. Frank,Mohamad Navab,Alan M. Fogelman,Aldons J. Lusis +13 more
TL;DR: Low HDL lipid levels exhibited complex inheritance, as 12 quantitative trait loci with significant or suggestive likelihood of observed data scores were identified and novel genes are likely to be important in the control of HDL metabolism.
Journal ArticleDOI
Systems genetics of susceptibility to obesity-induced diabetes in mice.
Richard C. Davis,Atila van Nas,Lawrence W. Castellani,Yi Zhao,Zhiqiang Zhou,Ping-Zi Wen,Suzanne Yu,Hongxiu Qi,Melenie Rosales,Eric E. Schadt,Karl W. Broman,Miklós Péterfy,Aldons J. Lusis +12 more
TL;DR: The results show that the genetics of diabetes susceptibility are enormously complex and a number of quantitative trait loci contributing to diabetes-related traits were identified, notably on chromosomes 4, 6, 7, 9, 10, 11, 12, and 19.
Journal ArticleDOI
Dissection of multigenic obesity traits in congenic mouse strains
Daria Estrada-Smith,Lawrence W. Castellani,Howard Wong,Ping-Zi Wen,Aileen Chui,Aldons J. Lusis,Richard C. Davis +6 more
TL;DR: Characterization of the MOB congenics localized the effects of genes that underlie obesity-related traits to an introgressed interval unique to the middle MOB congenic, whereas significant differences between the lipid and insulin profiles of the middle and distal Mob congenics implicated the presence of at least two genes thatUnderlie these traits.