G. S. Pope

TL;DR: Initial studies reported here show that parabens can be extracted from human breast tissue and detected by thin‐layer chromatography and this should open the way technically for more detailed information to be obtained on body burdens of paraben and in particular whether body burdens are different in cancer from those in normal tissues.

TL;DR: Molecular modelling has indicated the mode by which paraben molecules can bind into the ligand binding pocket of the crystal structure of the ligands binding domain (LBD) of the oestrogen receptor alpha (ERalpha) in place of 17beta-oestradiol, and has shown that two parabens molecules canbind simultaneously in a mode in which their phenolic hydroxyl groups bind similarly to those of the meso-hexoestrol molecule.

TL;DR: Seven of the eight phytoestrogens (all except resveratrol) gave similar maximal responses to that given by 17beta-oestradiol in cell-based assays, and the most marked difference was for coumestrol and 8-prenylnaringenin which both displayed a relatively potent ability to displace [3H]oest radiol from cytosolic ER compared with their much lower activity in the cell- based assays.

TL;DR: Results here show that branching of the alkyl chain to isobutylparaben increases oestrogenic activity beyond that of the equivalent length linear alkyL chain in n‐butyl paraben.

TL;DR: It is demonstrated that the oestrogenicity of methylparaben can be increased by the addition of an aryl group as well as by lengthening or branching the alkyl grouping.