G
G. Tim Bowden
Researcher at University of Arizona
Publications - 104
Citations - 5596
G. Tim Bowden is an academic researcher from University of Arizona. The author has contributed to research in topics: Carcinogenesis & Transactivation. The author has an hindex of 44, co-authored 104 publications receiving 5433 citations. Previous affiliations of G. Tim Bowden include Catholic University of Korea & National Institutes of Health.
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Journal ArticleDOI
Prevention of non-melanoma skin cancer by targeting ultraviolet-B-light signalling
TL;DR: Targeting key molecules in the ultraviolet-light signal-transduction pathway is being explored for early chemoprevention of non-melanoma skin cancer.
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UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression
Michael A Bachelor,G. Tim Bowden +1 more
TL;DR: It is proposed UVA-mediated increases in AP-1 and COX-2 may play a role in tumor promotion through increases in interleukin-8 (IL-8) and vascular endothelial growth factor (VEGF) and pharmacological inhibitors may be of benefit in the chemoprevention of non-melanoma skin cancer.
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Expression of metalloproteinase genes in human prostate cancer.
TL;DR: Northern blot analysis revealed that certain metalloproteinases are present in prostatic adenocarcinoma and may play a role in invasion and metastasis and in situ hybridization revealed that the MMP-7 gene was expressed in the epithelial cells of primary prostate adenOCarcinomas as well as in invasive and metastatic cells.
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Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines.
TL;DR: It is demonstrated that both MNNG and radiation-progressed malignant variants showed elevated ROS levels that contributed to their proliferative capacity in vitro as well as in vivo and increased Erk-1/2 and p38 MAP kinase activities were found to be important components of ROS-mediated signaling.
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Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine.
Ki Won Lee,Nam Joo Kang,Nam Joo Kang,Yong-Seok Heo,Evgeny A. Rogozin,Angelo Pugliese,Mun Kyung Hwang,G. Tim Bowden,Ann M. Bode,Hyong Joo Lee,Zigang Dong +10 more
TL;DR: It is reported that red wine extract or the red wine flavonoid quercetin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation of JB6 promotion-sensitive mouse skin epidermal (JB6 P+) cells.